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Bone Biosensors: Knowing the Present and Predicting the Future Publisher



Khashayar P1, 2, 3 ; Amoabediny G4, 5 ; Larijani B6 ; Vanfleteren J3
Authors
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Authors Affiliations
  1. 1. Nanobiotechnalogy Department, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
  2. 2. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Center for Microsystems Technology (CMST), Imec and Ghent University, Technologiepark, Ghent, Belgium
  4. 4. Department of Biotechnology, Faculty of Chemical Engineering, School of Engineering, University of Tehran, Tehran, Iran
  5. 5. Nanobiotechnology Department, Research Center for New Technology in Life Sciences Engineering, University of Tehran, Tehran, Iran
  6. 6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Micromechanics and Microengineering Published:2016


Abstract

Bone is an active organ with the capacity of continuous remodeling throughout adult life. In view of the fact that the current gold standard to assess bone remodeling, bone mineral density, suffers from certain limitations, newer techniques are being developed. Currently enzyme-linked immunosorbent assay is commonly used to assess bone turnover markers; the technique, however, is expensive, time consuming and needs trained personnel. Thus, there is a growing demand to fabricate different types of biosensors to provide low cost miniaturized platforms to assess the bone remodeling process more accurately. This review focuses on the latest advancements in the field of bone biosensing technologies. Its results might help provide possible solutions for translation of this technology for point-of-care diagnostic applications. © 2016 IOP Publishing Ltd.
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