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The Effects of Tumor-Derived Supernatants (Tds) on Cancer Cell Progression: A Review and Update on Carcinogenesis and Immunotherapy Publisher Pubmed



S Ahmadpour SAJJAD ; Ma Habibi Mohammad AMIN ; Fs Ghazi Farzaneh SADAT ; M Molazadeh MIKAEIL ; Mr Pashaie Mohammad REZA ; Y Mohammadpour YOUSEF
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Source: Cancer Treatment and Research Communications Published:2024


Abstract

Tumors can produce bioactive substances called tumor-derived supernatants (TDS) that modify the immune response in the host body. This can result in immunosuppressive effects that promote the growth and spread of cancer. During tumorigenesis, the exudation of these substances can disrupt the function of immune sentinels in the host and reinforce the support for cancer cell growth. Tumor cells produce cytokines, growth factors, and proteins, which contribute to the progression of the tumor and the formation of premetastatic niches. By understanding how cancer cells influence the host immune system through the secretion of these factors, we can gain new insights into cancer diagnosis and therapy. © 2024 Elsevier B.V., All rights reserved.
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