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The Crosstalk Between Exosomal Mirna and Ferroptosis: A Narrative Review Publisher Pubmed



Nashtahosseini Z1 ; Nejatollahi M2 ; Fazilat A3 ; Zarif Fakoor E4 ; Emamvirdizadeh A5 ; Bahadori K6 ; Hadian NS7 ; Valilo M8, 9
Authors
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Authors Affiliations
  1. 1. Department of Biology, University of Guilan, Rasht, Iran
  2. 2. Research center for high school students, Education System Zanjan Province, Zanjan, Iran
  3. 3. Department of Genetics, Motamed Cancer Institute, Breast Cancer Research Center, ACECR, Tehran, Iran
  4. 4. General biology, Payam-e noor university of Mashhad, Mashhad, Iran
  5. 5. Department of Genetics, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
  6. 6. Health center of Bahar, Hamadan University of Medical Science& Health Services, Hamadan, Iran
  7. 7. School of Biology, Damghan University, Damghan, Iran
  8. 8. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  9. 9. Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Source: Biology of the Cell Published:2025


Abstract

Abstract: Ferroptosis is a type of cell death that multiple mechanisms and pathways contribute to the positive and negative regulation of it. For example, increased levels of reactive oxygen species (ROS) induce ferroptosis. ferroptosis unlike apoptosis, it is not dependent on caspases, but is dependent on iron. Exosomes are membrane-bound vesicles with a size of about 30 to 150 nm, contain various cellular components, including DNA, RNA, microRNAs (miRNAs), lipids, and proteins, which are genetically similar to their cells of origin. Exosomes are found in all bodily fluids, including blood, saliva, and urine. Cells often release exosomes after their fusion with the cell membrane. They play an important role in immune regulation and cell-cell communication. miRNAs, which are noncoding RNAs with a length of about 18 to 24 nucleotides, are involved in regulating gene expression after transcription. Emerging data suggests that exosomal miRNAs are implicated in various pathophysiological mechanisms of cells, including metastasis, drug resistance, and cell death. In addition, functional studies have indicated that exosomal miRNAs can play a key role in the modulation of cell death by regulating ferroptosis. Therefore, in this review, given the importance of exosomal miRNAs in ferroptosis, we decided to elucidate the relationship between exosomal miRNAs and ferroptosis in various diseases. © 2025 Societe Francaise des Microscopies and Societe de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.
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