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Unveiling the Intersection: Ferroptosis in Influenza Virus Infection Publisher Pubmed



Letafati A1 ; Taghiabadi Z2 ; Ardekani OS3 ; Abbasi S1 ; Najafabadi AQ5 ; Jazi NN3 ; Soheili R6 ; Rodrigo R7 ; Yavarian J1 ; Saso L8
Authors
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Authors Affiliations
  1. 1. Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Microbiology and Virology of Medicine, Mashhad University of Medical Science, Mashhad, Iran
  3. 3. Department of Bacteriology & amp
  4. 4. Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran
  7. 7. Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
  8. 8. Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University, Rome, Italy

Source: Virology Journal Published:2024


Abstract

The influenza virus (IFV) imposes a considerable health and economic burden globally, requiring a comprehensive understanding of its pathogenic mechanisms. Ferroptosis, an iron-dependent lipid peroxidation cell death pathway, holds unique implications for the antioxidant defense system, with possible contributions to inflammation. This exploration focuses on the dynamic interplay between ferroptosis and the host defense against viruses, emphasizing the influence of IFV infections on the activation of the ferroptosis pathway. IFV causes different types of cell death, including apoptosis, necrosis, and ferroptosis. IFV-induced ferroptotic cell death is mediated by alterations in iron homeostasis, intensifying the accumulation of reactive oxygen species and promoting lipid peroxidation. A comprehensive investigation into the mechanism of ferroptosis in viral infections, specifically IFV, has great potential to identify therapeutic strategies. This understanding may pave the way for the development of drugs using ferroptosis inhibitors, presenting an effective approach to suppress viral infections. © The Author(s) 2024.