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One-Pot Synthesis of Oxoisoindoline-1,2,3-Triazole Hybrid by a Ugi–Click Reaction Publisher



Akrami S1 ; Firoozpour L2 ; Goligarmroodi F3 ; Moghimi S3 ; Mahdavi M2 ; Zonouzi A1 ; Foroumadi A2, 3, 4
Authors
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Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Source: Synthetic Communications Published:2016


Abstract

1,2,3-Triazole-3-oxoisoindoline-1-carboxamide system was successfully synthesized by using a combination of Ugi and click reactions. This two-step, one-pot synthesis was started by the reaction of 2-formyl benzoic acid, propargyl amine, and cyclohexyl isocyanide in ethanol. The resultant Ugi adduct underwent a copper-catalyzed click reaction, producing the desired products in good yields. © 2016, Copyright © Taylor & Francis Group, LLC.