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A Link Between Expression Level of Long-Non-Coding Rna Zfas1 in Breast Tissue of Healthy Women and Obesity Publisher Pubmed



Mansoori Y1, 2 ; Tabei MB3 ; Askari A2, 4 ; Izadi P1 ; Daraei A5 ; Naghizadeh MM2 ; Zendehbad Z1 ; Bastami M6, 7 ; Narimansalehfam Z8 ; Mansoori H2, 3 ; Tavakkolybazzaz J1
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Department of Medical Genetics, School of Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Bone and Joint Reconstraction Research Center, Shafa Orthopedic Haspital, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
  6. 6. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: International Journal of Biological Markers Published:2018


Abstract

Background: Epidemiological and experimental literature indicates that the risk of breast cancer incidence is strongly linked to hormone-dependent factors, including reproductive history and obesity. However, the molecular mechanisms underlying the association between these factors and breast cancer risk are poorly understood. The aim of this study, therefore, was to determine whether obesity and reproductive history are associated with expression levels of two breast cancer-related long non-coding RNAs (lncRNAs), namely ZFAS1 and SRA1 in cancer-free breast tissues of women. Methods: In the current research, 145 healthy women were recruited, and the quantitative expression levels of the two lncRNAs were determined through qPCR assay after gathering the mammoplasty breast tissue samples. Results: It was found that women with body mass index (BMI)≥30 kg/m2 and BMI 25–29 kg/m2 show a low expression of ZFAS1 compared to the BMI<25 kg/m2 (P=0.031 and P=0.027, respectively). Then, the correlation analysis disclosed a negative correlation of ZFAS1 low expression with increasing BMI (r=−0.194, P=0.019). Interestingly, this analysis demonstrated a negative correlation between low expression of the ZFAS1 and high BMI in women with menarche age below 14 (r=−221; P=0.028). Lastly, it was also revealed that there was a negative association of the low expression level of ZFAS1 with increasing BMI in women through regression models (B=−0.048, P=0.019). Conclusions: These findings suggest interesting clues about the links between high BMI and the expression levels of ZFAS1 in non-diseased breasts that may help us better understand the underlying mechanisms through which obesity contributes to breast carcinogenesis. However, such results need more validations in future research. © The Author(s) 2018.
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