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Breast Cancer-Linked Lncrna U-Eleanor Is Upregulated in Breast of Healthy Women With Lack or Short Duration of Breastfeeding Publisher Pubmed



Mansoori Y1 ; Zendehbad Z2 ; Askari A3 ; Kouhpayeh A4 ; Tavakkolybazzaz J2 ; Narimansalehfam Z5 ; Bastami M6 ; Saadatian Z7 ; Mansoori B1 ; Yousefvand A8 ; Mansoori H1 ; Daraei A9
Authors
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Authors Affiliations
  1. 1. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Orthopedy, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Pharmacology, Fasa University of Medical Sciences, Fasa, Iran
  5. 5. Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Immunology Research Center, Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  9. 9. Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Source: Journal of Cellular Biochemistry Published:2019


Abstract

Recently, it has been revealed that estrogen-related reproductive factors are linked with some early gene expression lesions associated with malignancy in clinically healthy breasts. Accordingly, the aim of the current study was to evaluate the association of expression levels of estrogen-related long noncoding RNAs (lncRNAs) upstream Eleanor (u-Eleanor) and HOX antisense intergenic RNA (HOTAIR) with the different patterns of reproductive factors in breast tissue of healthy women. The subjects of this study were 98 cancer-free women who had undergone cosmetic mammoplasty. The expression levels of u-Eleanor and HOTAIR were measured using quantitative real-time polymerase chain reaction. The results of the current study showed that the women without a history of breastfeeding had a high-level expression of u-Eleanor compared with the women with a breastfeeding duration greater than 6 to 24 months (P = 0.03) as well as the women with a breastfeeding duration of more than 24 months (P = 0.005). Furthermore, a higher expression of u-Eleanor was found in the women with a short breastfeeding duration for 1 to 6 months than that in the women with a breastfeeding duration of greater than 24 months (P = 0.02). In the same way, the results of correlation test (r = −0.258; P = 0.036) and multivariate regression model (β = −0.321; P = 0.023) are indicative of a significant relationship of elevated expression of u-Eleanor with decreasing breastfeeding duration in the women. These findings could be important to identify the molecular mechanisms behind the relationship between a lack or short duration of the breastfeeding and the risk of breast cancer, which has previously been reported by epidemiological studies. © 2018 Wiley Periodicals, Inc.
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