Hypoxia‐Inducible Factor 1 Alpha (Hif‐1Α) Stimulated and P2x7 Receptor Activated by Covid-19, As a Potential Therapeutic Target and Risk Factor for Epilepsy

Hypoxia‐Inducible Factor 1 Alpha (Hif‐1Α) Stimulated and P2x7 Receptor Activated by Covid-19, As a Potential Therapeutic Target and Risk Factor for Epilepsy Publisher Pubmed

Zalpoor H^{1, 2} ; Akbari A^{1, 2} ; Nabiafjadi M³ ; Forghaniesfidvajani R² ; Tavakol C⁴ ; Barzegar Z¹ ; Iravanpour F¹ ; Hosseini M¹ ; Mousavi SR^{1, 5} ; Farrokhi MR^{1, 5}

Show Affiliations

1. Department of Neurosurgery, Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2. Network of Immunity in Infection, Malignancy & Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN), Tehran, Iran
3. Department of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran
4. Medical School, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Human Cell Published:2022

Abstract

Based on available evidence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a neuroinvasive virus. According to the centers for disease control and prevention (CDC), coronavirus disease 2019 (COVID-19) may cause epilepsy. In this line, COVID-19 can stimulate hypoxia-inducible factor-1 alpha (HIF-1α) and activate P2X7 receptor. Both HIF-1α and P2X7 receptors are linked to epileptogenesis and seizures. Therefore, in the current study, we suggested that COVID-19 may have a role in epileptogenesis and seizure through HIF-1α stimulation and P2X7 receptor activation. Consequently, pharmacological targeting of these factors could be a promising therapeutic approach for such patients. © 2022, The Author(s) under exclusive licence to Japan Human Cell Society.

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Style	Citing Format
MLA	Zalpoor H, et al.. "Hypoxia‐Inducible Factor 1 Alpha (Hif‐1Α) Stimulated and P2x7 Receptor Activated by Covid-19, As a Potential Therapeutic Target and Risk Factor for Epilepsy." Human Cell, vol. 35, no. 5, 2022, pp. 1338-1345.
APA	Zalpoor H, Akbari A, Nabiafjadi M, Forghaniesfidvajani R, Tavakol C, Barzegar Z, Iravanpour F, Hosseini M, Mousavi SR, Farrokhi MR (2022). Hypoxia‐Inducible Factor 1 Alpha (Hif‐1Α) Stimulated and P2x7 Receptor Activated by Covid-19, As a Potential Therapeutic Target and Risk Factor for Epilepsy. Human Cell, 35(5), 1338-1345.
Chicago	Zalpoor H, Akbari A, Nabiafjadi M, Forghaniesfidvajani R, Tavakol C, Barzegar Z, Iravanpour F, Hosseini M, Mousavi SR, Farrokhi MR. "Hypoxia‐Inducible Factor 1 Alpha (Hif‐1Α) Stimulated and P2x7 Receptor Activated by Covid-19, As a Potential Therapeutic Target and Risk Factor for Epilepsy." Human Cell 35, no. 5 (2022): 1338-1345.
Harvard	Zalpoor H et al. (2022) 'Hypoxia‐Inducible Factor 1 Alpha (Hif‐1Α) Stimulated and P2x7 Receptor Activated by Covid-19, As a Potential Therapeutic Target and Risk Factor for Epilepsy', Human Cell, 35(5), pp. 1338-1345.
Vancouver	Zalpoor H, Akbari A, Nabiafjadi M, Forghaniesfidvajani R, Tavakol C, Barzegar Z, et al.. Hypoxia‐Inducible Factor 1 Alpha (Hif‐1Α) Stimulated and P2x7 Receptor Activated by Covid-19, As a Potential Therapeutic Target and Risk Factor for Epilepsy. Human Cell. 2022;35(5):1338-1345.
BibTex	@article{ author = {Zalpoor H and Akbari A and Nabiafjadi M and Forghaniesfidvajani R and Tavakol C and Barzegar Z and Iravanpour F and Hosseini M and Mousavi SR and Farrokhi MR}, title = {Hypoxia‐Inducible Factor 1 Alpha (Hif‐1Α) Stimulated and P2x7 Receptor Activated by Covid-19, As a Potential Therapeutic Target and Risk Factor for Epilepsy}, journal = {Human Cell}, volume = {35}, number = {5}, pages = {1338-1345}, year = {2022} }
RIS	TY - JOUR AU - Zalpoor H AU - Akbari A AU - Nabiafjadi M AU - Forghaniesfidvajani R AU - Tavakol C AU - Barzegar Z AU - Iravanpour F AU - Hosseini M AU - Mousavi SR AU - Farrokhi MR TI - Hypoxia‐Inducible Factor 1 Alpha (Hif‐1Α) Stimulated and P2x7 Receptor Activated by Covid-19, As a Potential Therapeutic Target and Risk Factor for Epilepsy JO - Human Cell VL - 35 IS - 5 SP - 1338 EP - 1345 PY - 2022 ER -

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