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Possible Transmission Flow of Sars-Cov-2 Based on Ace2 Features Publisher Pubmed



Hassan SS1 ; Ghosh S2 ; Attrish D3 ; Choudhury PP4 ; Aljabali AAA5 ; Uhal BD6 ; Lundstrom K7 ; Rezaei N8, 9 ; Uversky VN10 ; Seyran M11 ; Pizzol D12 ; Adadi P13 ; Soares A14 ; Abd Elaziz TM14, 15 Show All Authors
Authors
  1. Hassan SS1
  2. Ghosh S2
  3. Attrish D3
  4. Choudhury PP4
  5. Aljabali AAA5
  6. Uhal BD6
  7. Lundstrom K7
  8. Rezaei N8, 9
  9. Uversky VN10
  10. Seyran M11
  11. Pizzol D12
  12. Adadi P13
  13. Soares A14
  14. Abd Elaziz TM14, 15
  15. Kandimalla R16, 17
  16. Tambuwala MM18
  17. Azad GK19
  18. Sherchan SP20
  19. Baetasdacruz W21
  20. Takayama K22
  21. Serranoaroca A23
  22. Chauhan G24
  23. Palu G25
  24. Brufsky AM26
Show Affiliations
Authors Affiliations
  1. 1. Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, 721140, India
  2. 2. Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata, 700009, India
  3. 3. Dr. B. R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi (North Campus), Delhi, 110007, India
  4. 4. Applied Statistics Unit, Indian Statistical Institute, West Bengal, Kolkata, 700108, India
  5. 5. Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid, 566, Jordan
  6. 6. Department of Physiology, Michigan State University, East Lansing, 48824, MI, United States
  7. 7. PanTherapeutics, Rte de Lavaux 49, Lutry, CH1095, Switzerland
  8. 8. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  9. 9. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, SE-123, Sweden
  10. 10. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, 33612, FL, United States
  11. 11. Doctoral studies in natural and technical sciences (SPL 44), University of Vienna, Wien, 1010, Austria
  12. 12. Italian Agency for Development Cooperation—Khartoum, Sudan Street 33, Al Amarat, Khartoum, 825109, Sudan
  13. 13. Department of Food Science, University of Otago, Dunedin, 9054, New Zealand
  14. 14. Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, 77030, TX, United States
  15. 15. Zoology Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt
  16. 16. Applied Biology, CSIR-Indian Institute of Chemical Technology Uppal Road, Tarnaka, Hyderabad, 500007, India
  17. 17. Department of Biochemistry, Kakatiya Medical College, Telangana, Warangal, 500022, India
  18. 18. School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, BT52 1SA, United Kingdom
  19. 19. Department of Zoology, Patna University, Bihar, Patna, 800005, India
  20. 20. Department of Environmental Health Sciences, Tulane University, New Orleans, 70112, LA, United States
  21. 21. Translational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, 21941901, Brazil
  22. 22. Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8501, Japan
  23. 23. Biomaterials and Bioengineering Lab, Translational Research Centre San Alberto Magno, Catholic University of Valencia San Vicente Martir, c/Guillem de Castro 94, Valencia, 46001, Spain
  24. 24. School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, Nuevo Leon, Monterrey, 64849, Mexico
  25. 25. Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova, 35121, Italy
  26. 26. Division of Hematology/Oncology, Department of Medicine, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, 15260, PA, United States

Source: Molecules Published:2020


Abstract

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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