The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies

The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies Publisher Pubmed

Zalpoor H^{1, 2, 3} ; Akbari A⁴ ; Samei A⁵ ; Forghaniesfidvajani R⁴ ; Kamali M⁶ ; Afzalnia A⁶ ; Manshouri S⁶ ; Heidari F⁷ ; Pornour M⁸ ; Khoshmirsafa M⁹ ; Aazami H¹⁰ ; Seif F^{2, 11}

Show Affiliations

1. American Association of Kidney Patients, Tampa, FL, United States
2. Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran
3. Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
5. Department of Laboratory Sciences, School of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran
6. Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
7. Immunology Department, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran
8. Department of Oncology, School of Medicine, University of Maryland, MD, United States
9. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Iran
10. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
11. Department of Immunology and Allergy, Academic Center for Education, Culture, and Research (ACECR), Enghelab St., Aboureyhan St., Vahid Nazari Crossroad, P17, Tehran, 1315795613, Iran

Source: Cellular and Molecular Biology Letters Published:2022

Abstract

The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, elucidation of pathogenesis mechanisms, especially entry routes of SARS-CoV-2 may help propose antiviral drugs and novel vaccines. Several receptors have been demonstrated for the interaction of spike (S) protein of SARS-CoV-2 with host cells, including angiotensin-converting enzyme (ACE2), ephrin ligands and Eph receptors, neuropilin 1 (NRP-1), P2X7, and CD147. The expression of these entry receptors in the central nervous system (CNS) may make the CNS prone to SARS-CoV-2 invasion, leading to neurodegenerative diseases. The present review provides potential pathological mechanisms of SARS-CoV-2 infection in the CNS, including entry receptors and cytokines involved in neuroinflammatory conditions. Moreover, it explains several neurodegenerative disorders associated with COVID-19. Finally, we suggest inflammasome and JaK inhibitors as potential therapeutic strategies for neurodegenerative diseases. © 2022, The Author(s).

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Style	Citing Format
MLA	Zalpoor H, et al.. "The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies." Cellular and Molecular Biology Letters, vol. 27, no. 1, 2022, pp. -.
APA	Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, Manshouri S, Heidari F, Pornour M, Khoshmirsafa M, Aazami H, Seif F (2022). The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies. Cellular and Molecular Biology Letters, 27(1), -.
Chicago	Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, Manshouri S, et al.. "The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies." Cellular and Molecular Biology Letters 27, no. 1 (2022): -.
Harvard	Zalpoor H et al. (2022) 'The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies', Cellular and Molecular Biology Letters, 27(1), pp. -.
Vancouver	Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, et al.. The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies. Cellular and Molecular Biology Letters. 2022;27(1):-.
BibTex	@article{ author = {Zalpoor H and Akbari A and Samei A and Forghaniesfidvajani R and Kamali M and Afzalnia A and Manshouri S and Heidari F and Pornour M and Khoshmirsafa M and Aazami H and Seif F}, title = {The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies}, journal = {Cellular and Molecular Biology Letters}, volume = {27}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Zalpoor H AU - Akbari A AU - Samei A AU - Forghaniesfidvajani R AU - Kamali M AU - Afzalnia A AU - Manshouri S AU - Heidari F AU - Pornour M AU - Khoshmirsafa M AU - Aazami H AU - Seif F TI - The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies JO - Cellular and Molecular Biology Letters VL - 27 IS - 1 SP - EP - PY - 2022 ER -

Style

Citing Format

MLA

Zalpoor H, et al.. "The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies." Cellular and Molecular Biology Letters, vol. 27, no. 1, 2022, pp. -.

APA

Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, Manshouri S, Heidari F, Pornour M, Khoshmirsafa M, Aazami H, Seif F (2022). The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies. Cellular and Molecular Biology Letters, 27(1), -.

Chicago

Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, Manshouri S, et al.. "The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies." Cellular and Molecular Biology Letters 27, no. 1 (2022): -.

Harvard

Zalpoor H et al. (2022) 'The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies', Cellular and Molecular Biology Letters, 27(1), pp. -.

Vancouver

Zalpoor H, Akbari A, Samei A, Forghaniesfidvajani R, Kamali M, Afzalnia A, et al.. The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies. Cellular and Molecular Biology Letters. 2022;27(1):-.

BibTex

@article{ author = {Zalpoor H and Akbari A and Samei A and Forghaniesfidvajani R and Kamali M and Afzalnia A and Manshouri S and Heidari F and Pornour M and Khoshmirsafa M and Aazami H and Seif F}, title = {The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies}, journal = {Cellular and Molecular Biology Letters}, volume = {27}, number = {1}, pages = {-}, year = {2022} }

RIS

TY - JOUR
AU - Zalpoor H
AU - Akbari A
AU - Samei A
AU - Forghaniesfidvajani R
AU - Kamali M
AU - Afzalnia A
AU - Manshouri S
AU - Heidari F
AU - Pornour M
AU - Khoshmirsafa M
AU - Aazami H
AU - Seif F
TI - The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies
JO - Cellular and Molecular Biology Letters
VL - 27
IS - 1
SP -
EP -
PY - 2022
ER -

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