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Electroconductive Scaffolds for Tissue Regeneration: Current Opportunities, Pitfalls, and Potential Solutions Publisher



Nekounam H1, 5 ; Gholizadeh S2, 3 ; Allahyari Z2, 3 ; Samadian H4 ; Nazeri N1 ; Shokrgozar MA5 ; Faridimajidi R1
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Microsystems Engineering, Rochester Institute of Technology, 160 Lomb Memorial Drive, Rochester, 14623, NY, United States
  3. 3. Department of Biomedical Engineering, Rochester Institute of Technology, 160 Lomb Memorial Drive, Rochester, 14623, NY, United States
  4. 4. Nano Drug Delivery Research Centre, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, 1316943551, Iran

Source: Materials Research Bulletin Published:2021


Abstract

In recent years, conductive scaffolds have increasingly found applications as biomaterials, serving for effective delivery of electrical cues to cells. Mimicking the structure of the native extracellular matrix and electrical stimulation of damaged tissues have been suggested to be highly beneficial for tissue regeneration. This review provides a critical overview of progress in designing and using electro-conductive nanostructured scaffolds for tissue engineering with more emphasis on recent studies. A significant majority of these nanostructures include carbon-based nanomaterials, conductive polymers, and conductive nanocomposites. We describe cellular responses to electrical stimulation achieved by conductive scaffolds and also highlight and discuss successful outcomes and challenges related to their applications. Although every previous work in this area of research is not singled out, we aim to outline the specific potentials and pitfalls of works on each tissue. Additionally, tissue-specific requirements for electroconductive scaffolds and associated opportunities for future research and challenges are addressed. © 2020
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