Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency

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Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency Publisher Pubmed

Yazdani R^{1, 2, 3} ; Ganjalikhanihakemi M¹ ; Esmaeili M⁴ ; Abolhassani H^{2, 5} ; Vaeli S⁴ ; Rezaei A¹ ; Sharifi Z⁴ ; Azizi G⁶ ; Rezaei N^{2, 7, 8} ; Aghamohammadi A^{2, 9}

Show Affiliations

1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
3. Molecular Immunology Interest Group (MIIG), Universal Scientific Education and Research Network (USERN), Isfahan, Iran
4. Department of Virology, Iranian Blood Transfusion Organization, Tehran, Iran
5. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden
6. Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
7. Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
8. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, United States
9. Primary Immunodeficiency Disease Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Clinical Immunology Published:2017

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency characterized by recurrent infections. We evaluated whether defective PI3K/Akt/FoxO pathway could influence B-cell fate. Determination of B-cell subsets in CVD patients and healthy donors (HDs) were performed using flow cytometry. We evaluated mRNA and protein expression of PI3K, Akt and FoxO using real-time PCR and flow cytometry, respectively. Moreover, phosphorylated Akt (pAkt) expression in B-cells has been measured by flowcytometry. We identified a significant reduction in the percentage of marginal zone like B-cells, memory B-cells (total, switched and unswitched) and plasmablasts in patients, as these decreased B-cell subsets had a significant negative correlation with increased apoptosis in patients. Surprisingly, we identified decreased pAkt expression in B-cells of patients than HDs. We described for the first time impaired pAkt expression in B-cells of CVID patients that had a significant correlation with antibody response to the vaccine and worse clinical complications. © 2016 Elsevier Inc.

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Style	Citing Format
MLA	Yazdani R, et al.. "Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency." Clinical Immunology, vol. 175, no. , 2017, pp. 124-132.
APA	Yazdani R, Ganjalikhanihakemi M, Esmaeili M, Abolhassani H, Vaeli S, Rezaei A, Sharifi Z, Azizi G, Rezaei N, Aghamohammadi A (2017). Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency. Clinical Immunology, 175(), 124-132.
Chicago	Yazdani R, Ganjalikhanihakemi M, Esmaeili M, Abolhassani H, Vaeli S, Rezaei A, Sharifi Z, Azizi G, Rezaei N, Aghamohammadi A. "Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency." Clinical Immunology 175, no. (2017): 124-132.
Harvard	Yazdani R et al. (2017) 'Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency', Clinical Immunology, 175(), pp. 124-132.
Vancouver	Yazdani R, Ganjalikhanihakemi M, Esmaeili M, Abolhassani H, Vaeli S, Rezaei A, et al.. Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency. Clinical Immunology. 2017;175():124-132.
BibTex	@article{ author = {Yazdani R and Ganjalikhanihakemi M and Esmaeili M and Abolhassani H and Vaeli S and Rezaei A and Sharifi Z and Azizi G and Rezaei N and Aghamohammadi A}, title = {Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency}, journal = {Clinical Immunology}, volume = {175}, number = {}, pages = {124-132}, year = {2017} }
RIS	TY - JOUR AU - Yazdani R AU - Ganjalikhanihakemi M AU - Esmaeili M AU - Abolhassani H AU - Vaeli S AU - Rezaei A AU - Sharifi Z AU - Azizi G AU - Rezaei N AU - Aghamohammadi A TI - Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency JO - Clinical Immunology VL - 175 IS - SP - 124 EP - 132 PY - 2017 ER -

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