Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency

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Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency Publisher Pubmed

Yazdani R^{1, 2, 3} ; Ganjalikhanihakemi M¹ ; Esmaeili M⁴ ; Abolhassani H^{2, 5} ; Vaeli S⁴ ; Rezaei A¹ ; Sharifi Z⁴ ; Azizi G⁶ ; Rezaei N^{2, 7, 8} ; Aghamohammadi A^{2, 9}

Source: Clinical Immunology Published:2017

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency characterized by recurrent infections. We evaluated whether defective PI3K/Akt/FoxO pathway could influence B-cell fate. Determination of B-cell subsets in CVD patients and healthy donors (HDs) were performed using flow cytometry. We evaluated mRNA and protein expression of PI3K, Akt and FoxO using real-time PCR and flow cytometry, respectively. Moreover, phosphorylated Akt (pAkt) expression in B-cells has been measured by flowcytometry. We identified a significant reduction in the percentage of marginal zone like B-cells, memory B-cells (total, switched and unswitched) and plasmablasts in patients, as these decreased B-cell subsets had a significant negative correlation with increased apoptosis in patients. Surprisingly, we identified decreased pAkt expression in B-cells of patients than HDs. We described for the first time impaired pAkt expression in B-cells of CVID patients that had a significant correlation with antibody response to the vaccine and worse clinical complications. © 2016 Elsevier Inc.

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Style	Citing Format
MLA	Yazdani R, et al.. "Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency." Clinical Immunology, vol. 175, no. , 2017, pp. 124-132.
APA	Yazdani R, Ganjalikhanihakemi M, Esmaeili M, Abolhassani H, Vaeli S, Rezaei A, Sharifi Z, Azizi G, Rezaei N, Aghamohammadi A (2017). Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency. Clinical Immunology, 175(), 124-132.
Chicago	Yazdani R, Ganjalikhanihakemi M, Esmaeili M, Abolhassani H, Vaeli S, Rezaei A, Sharifi Z, Azizi G, Rezaei N, Aghamohammadi A. "Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency." Clinical Immunology 175, no. (2017): 124-132.
Harvard	Yazdani R et al. (2017) 'Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency', Clinical Immunology, 175(), pp. 124-132.
Vancouver	Yazdani R, Ganjalikhanihakemi M, Esmaeili M, Abolhassani H, Vaeli S, Rezaei A, et al.. Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency. Clinical Immunology. 2017;175():124-132.
BibTex	@article{ author = {Yazdani R and Ganjalikhanihakemi M and Esmaeili M and Abolhassani H and Vaeli S and Rezaei A and Sharifi Z and Azizi G and Rezaei N and Aghamohammadi A}, title = {Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency}, journal = {Clinical Immunology}, volume = {175}, number = {}, pages = {124-132}, year = {2017} }
RIS	TY - JOUR AU - Yazdani R AU - Ganjalikhanihakemi M AU - Esmaeili M AU - Abolhassani H AU - Vaeli S AU - Rezaei A AU - Sharifi Z AU - Azizi G AU - Rezaei N AU - Aghamohammadi A TI - Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency JO - Clinical Immunology VL - 175 IS - SP - 124 EP - 132 PY - 2017 ER -

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