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Towards the Development of Sensation-Enabled Skin Substitutes Publisher Pubmed



Moradikhah F1 ; Farahani M1, 2 ; Shafiee A3
Authors
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Authors Affiliations
  1. 1. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  2. 2. Institute of Biomaterials, University of Tehran, Tehran University of Medical Sciences (IBUTUMS), Tehran, Iran
  3. 3. Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, 4102, QLD, Australia

Source: Biomaterials Science Published:2024


Abstract

Recent advances in cell and biofabrication technologies have contributed to the development of complex human organs. In particular, several skin substitutes are being generated using tissue engineering and regenerative medicine (TERM) technologies. However, recent studies mainly focus on the restoration of the dermis and epidermis layers rather than the regeneration of a fully functional innervated skin organ. Innervation is a critical step in functional tissue repair which has been overlooked in the current TERM studies. In the current study, we highlight the importance of sensation in the skin as the largest sensory organ in the human body. In large non-healing skin wounds, the skin sensation is severely diminished or completely lost and ultimately lead to chronic pain and wound healing process interruption. Current therapeutics for restoring skin sensation after trauma are limited. Recent regenerative medicine-based studies could successfully induce neural networks in skin substitutes, but the effectiveness of these technologies in enhancing sensory capability needs further investigation. © 2024 The Royal Society of Chemistry.
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