Next Generation Sequencing: Implications in Personalized Medicine and Pharmacogenomics

Next Generation Sequencing: Implications in Personalized Medicine and Pharmacogenomics Publisher Pubmed

Rabbani B¹ ; Nakaoka H² ; Akhondzadeh S³ ; Tekin M⁴ ; Mahdieh N¹

Show Affiliations

1. Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Niayesh-Vali Asr Intersection, Tehran, Iran
2. Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan
3. Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran
4. John P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, United States

Source: Molecular BioSystems Published:2016

Abstract

A breakthrough in next generation sequencing (NGS) in the last decade provided an unprecedented opportunity to investigate genetic variations in humans and their roles in health and disease. NGS offers regional genomic sequencing such as whole exome sequencing of coding regions of all genes, as well as whole genome sequencing. RNA-seq offers sequencing of the entire transcriptome and ChIP-seq allows for sequencing the epigenetic architecture of the genome. Identifying genetic variations in individuals can be used to predict disease risk, with the potential to halt or retard disease progression. NGS can also be used to predict the response to or adverse effects of drugs or to calculate appropriate drug dosage. Such a personalized medicine also provides the possibility to treat diseases based on the genetic makeup of the patient. Here, we review the basics of NGS technologies and their application in human diseases to foster human healthcare and personalized medicine. © 2016 The Royal Society of Chemistry.

Style	Citing Format
MLA	Rabbani B, et al.. "Next Generation Sequencing: Implications in Personalized Medicine and Pharmacogenomics." Molecular BioSystems, vol. 12, no. 6, 2016, pp. 1818-1830.
APA	Rabbani B, Nakaoka H, Akhondzadeh S, Tekin M, Mahdieh N (2016). Next Generation Sequencing: Implications in Personalized Medicine and Pharmacogenomics. Molecular BioSystems, 12(6), 1818-1830.
Chicago	Rabbani B, Nakaoka H, Akhondzadeh S, Tekin M, Mahdieh N. "Next Generation Sequencing: Implications in Personalized Medicine and Pharmacogenomics." Molecular BioSystems 12, no. 6 (2016): 1818-1830.
Harvard	Rabbani B et al. (2016) 'Next Generation Sequencing: Implications in Personalized Medicine and Pharmacogenomics', Molecular BioSystems, 12(6), pp. 1818-1830.
Vancouver	Rabbani B, Nakaoka H, Akhondzadeh S, Tekin M, Mahdieh N. Next Generation Sequencing: Implications in Personalized Medicine and Pharmacogenomics. Molecular BioSystems. 2016;12(6):1818-1830.
BibTex	@article{ author = {Rabbani B and Nakaoka H and Akhondzadeh S and Tekin M and Mahdieh N}, title = {Next Generation Sequencing: Implications in Personalized Medicine and Pharmacogenomics}, journal = {Molecular BioSystems}, volume = {12}, number = {6}, pages = {1818-1830}, year = {2016} }
RIS	TY - JOUR AU - Rabbani B AU - Nakaoka H AU - Akhondzadeh S AU - Tekin M AU - Mahdieh N TI - Next Generation Sequencing: Implications in Personalized Medicine and Pharmacogenomics JO - Molecular BioSystems VL - 12 IS - 6 SP - 1818 EP - 1830 PY - 2016 ER -

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Abstract