Multiple Functions of P27 in Cell Cycle, Apoptosis, Epigenetic Modification and Transcriptional Regulation for the Control of Cell Growth: A Double-Edged Sword Protein

Multiple Functions of P27 in Cell Cycle, Apoptosis, Epigenetic Modification and Transcriptional Regulation for the Control of Cell Growth: A Double-Edged Sword Protein Publisher Pubmed

Abbastabar M⁴ ; Kheyrollah M⁵ ; Azizian K⁶ ; Bagherlou N⁷ ; Tehrani SS^{1, 3} ; Maniati M⁸ ; Karimian A^{1, 2, 3}

Show Affiliations

1. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2. Cancer & Immunology Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
3. Student Research Committee, Babol University of Medical Sciences, Babol, Iran
4. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
6. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Science, Tabriz, Iran
7. Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
8. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: DNA Repair Published:2018

Abstract

The cell cycle is controlled by precise mechanisms to prevent malignancies such as cancer, and the cell needs these tight and advanced controls. Cyclin dependent kinase inhibitor p27 (also known as KIP1) is a factor that inhibits the progression of the cell cycle by using specific molecular mechanisms. The inhibitory effect of p27 on the cell cycle is mediated by CDKs inhibition. Other important functions of p27 include cell proliferation, cell differentiation and apoptosis. Post- translational modification of p27 by phosphorylation and ubiquitination respectively regulates interaction between p27 and cyclin/CDK complex and degradation of p27. In this review, we focus on the multiple function of p27 in cell cycle regulation, apoptosis, epigenetic modifications and post- translational modification, and briefly discuss the mechanisms and factors that have important roles in p27 functions. © 2018

Related Docs

View other Related Docs

1. Modulation of Cancer Cell Signaling by Long Noncoding Rnas, Journal of Cellular Biochemistry (2019)

2. Epi-Drugs and Epi-Mirs: Moving Beyond Current Cancer Therapies, Current Cancer Drug Targets (2016)

3. Effects of Chitosan and Oligochitosans on the Phosphatidylinositol 3-Kinase-Akt Pathway in Cancer Therapy, International Journal of Biological Macromolecules (2020)

4. The Effect of Mir-340 Over-Expression on Cell-Cycle–Related Genes in Triple-Negative Breast Cancer Cells, European Journal of Cancer Care (2017)

5. Cancer Genetics at a Glance: The Comprehensive Insights, Cancer Genetics and Psychotherapy (2017)

6. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4Th Edition)1, Autophagy (2021)

7. Dead-End Protein Expression, Function, and Mutation in Cancer: A Systematic Review, Molecular Biology Reports (2025)

8. Melatonin and 5-Fluorouracil Combination Chemotherapy: Opportunities and Efficacy in Cancer Therapy, Cell Communication and Signaling (2023)

Experts (# of related papers)

View all Related Experts

Mohammad Vasei (2)

Hamid Reza Mirzaei (2)

Style	Citing Format
MLA	Abbastabar M, et al.. "Multiple Functions of P27 in Cell Cycle, Apoptosis, Epigenetic Modification and Transcriptional Regulation for the Control of Cell Growth: A Double-Edged Sword Protein." DNA Repair, vol. 69, no. , 2018, pp. 63-72.
APA	Abbastabar M, Kheyrollah M, Azizian K, Bagherlou N, Tehrani SS, Maniati M, Karimian A (2018). Multiple Functions of P27 in Cell Cycle, Apoptosis, Epigenetic Modification and Transcriptional Regulation for the Control of Cell Growth: A Double-Edged Sword Protein. DNA Repair, 69(), 63-72.
Chicago	Abbastabar M, Kheyrollah M, Azizian K, Bagherlou N, Tehrani SS, Maniati M, Karimian A. "Multiple Functions of P27 in Cell Cycle, Apoptosis, Epigenetic Modification and Transcriptional Regulation for the Control of Cell Growth: A Double-Edged Sword Protein." DNA Repair 69, no. (2018): 63-72.
Harvard	Abbastabar M et al. (2018) 'Multiple Functions of P27 in Cell Cycle, Apoptosis, Epigenetic Modification and Transcriptional Regulation for the Control of Cell Growth: A Double-Edged Sword Protein', DNA Repair, 69(), pp. 63-72.
Vancouver	Abbastabar M, Kheyrollah M, Azizian K, Bagherlou N, Tehrani SS, Maniati M, et al.. Multiple Functions of P27 in Cell Cycle, Apoptosis, Epigenetic Modification and Transcriptional Regulation for the Control of Cell Growth: A Double-Edged Sword Protein. DNA Repair. 2018;69():63-72.
BibTex	@article{ author = {Abbastabar M and Kheyrollah M and Azizian K and Bagherlou N and Tehrani SS and Maniati M and Karimian A}, title = {Multiple Functions of P27 in Cell Cycle, Apoptosis, Epigenetic Modification and Transcriptional Regulation for the Control of Cell Growth: A Double-Edged Sword Protein}, journal = {DNA Repair}, volume = {69}, number = {}, pages = {63-72}, year = {2018} }
RIS	TY - JOUR AU - Abbastabar M AU - Kheyrollah M AU - Azizian K AU - Bagherlou N AU - Tehrani SS AU - Maniati M AU - Karimian A TI - Multiple Functions of P27 in Cell Cycle, Apoptosis, Epigenetic Modification and Transcriptional Regulation for the Control of Cell Growth: A Double-Edged Sword Protein JO - DNA Repair VL - 69 IS - SP - 63 EP - 72 PY - 2018 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract