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Role of Non-Coding Rnas As New Therapeutic Targets in Regulating the Emt and Apoptosis in Metastatic Gastric and Colorectal Cancers Publisher Pubmed



Ebrahimi N1 ; Hakimzadeh A2 ; Bozorgmand F3 ; Speed S4 ; Manavi MS5 ; Khorram R6 ; Farahani K7 ; Rezaeitazangi F8 ; Mansouri A9 ; Hamblin MR10, 11 ; Aref AR12, 13
Authors
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Authors Affiliations
  1. 1. Genetics Division, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Iran
  2. 2. Department of Medical Biotechnologies, University of Siena, Tuscany, Italy
  3. 3. Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  4. 4. Xi’an Jiaotong University, Medical Campus, Shaanxi, Xi’an, China
  5. 5. Otolaryngology Department, Tehran University of Medical Science, Tehran, Iran
  6. 6. Bone and Joint Diseases Research Center, Department of Orthopedic Surgery, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
  8. 8. Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  9. 9. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  10. 10. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa
  11. 11. Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran
  12. 12. Xsphera Biosciences, Translational Medicine group, Boston, MA, United States
  13. 13. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States

Source: Cell Cycle Published:2023


Abstract

Colorectal cancer (CRC) and gastric cancer (GC), are the two most common cancers of the gastrointestinal tract, and are serious health concerns worldwide. The discovery of more effective biomarkers for early diagnosis, and improved patient prognosis is important. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), can regulate cellular processes such as apoptosis and the epithelial-mesenchymal transition (EMT) leading to progression and resistance of GC and CRC tumors. Moreover these pathways (apoptosis and EMT) may serve as therapeutic targets, to prevent metastasis, and to overcome drug resistance. A subgroup of ncRNAs is common to both GC and CRC tumors, suggesting that they might be used as biomarkers or therapeutic targets. In this review, we highlight some ncRNAs that can regulate EMT and apoptosis as two opposite mechanisms in cancer progression and metastasis in GC and CRC. A better understanding of the biological role of ncRNAs could open up new avenues for the development of personalized treatment plans for GC and CRC patients. © 2023 Informa UK Limited, trading as Taylor & Francis Group.
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