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Efficacy of Tadalafil on Improvement of Men With Erectile Dysfunction Caused by Covid-19: A Randomized Placebo-Controlled Trial Publisher



Shamohammadi I1 ; Kazemeyni S2 ; Sadighi M2 ; Hasanzadeh T1 ; Dizavi A2
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Authors Affiliations
  1. 1. Department of Urology, Nemazee Hospital, Shiraz University of Medical Science, Shiraz, Iran
  2. 2. Department of Urology, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran

Source: Asian Journal of Urology Published:2024


Abstract

Objective: According to the high prevalence of COVID-19 and the subsequent risk of men's sexual health, we decided to investigate the efficacy of tadalafil on improvement of men with erectile dysfunction caused by COVID-19. Methods: In this study, 70 outpatients who were recovered from COVID-19 without acute respiratory distress syndrome with negative polymerase chain reaction test and a complaint of erectile dysfunction were divided into two groups: 35 patients who received tadalafil 5 mg daily and 35 who received placebo. For each patient, basic assessment of sexual function was performed using the 5-item version of the International Index of Erectile Function (IIEF-5) questionnaire. Then, treatment was started from 2 months after complete recovery of COVID-19 with negative polymerase chain reaction test for 3 months. At the end of the treatments, the patients were re-evaluated for sexual function using the complete version of IIEF questionnaire. Finally, the results before and after treatment in the intervention group were compared with those of the control group. Results: Treatment with both tadalafil and placebo improved the patients' sexual function criteria compared to the baseline. However, this improvement was significantly higher in the intervention group with tadalafil than the control group with placebo (p<0.05). Conclusion: Daily administration of tadalafil 5 mg seems to be effective and safe for improvement of erectile dysfunction caused by COVID-19. © 2024 Editorial Office of Asian Journal of Urology
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