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Effects of Human Nucleolus Upon Guest Viral-Life, Focusing in Covid-19 Infection: A Mini-Review Publisher



Bahadori M1 ; Azizi MH2 ; Dabiri S3 ; Bahadori N4
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Academy of Medical Sciences of Iran, Tehran, Iran
  3. 3. Department of Pathology, Pathology and Stem Cells Research Center, Afzalipour Medical School, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pathology Published:2022


Abstract

The nucleolus is a subcellular membrane-less structure of eukaryotic cells. In 1965, in a world’s southern summer summit in Uruguay, the role of the nucleolus as the site of ribosome synthesis, biogenesis, and processing of tRNA was conclusively established. Today, accumulating evidence confirm the multiple functions of the nucleolus, including tRNA precursor processing, cell stress sensing, as well as being influential in gene silencing, senescence, lifespan, DNA damage response (DDR), and cell cycle regulation. Therefore, nucleolopathy is observed in various human diseases. Modern advances have provided fundamental insights concerning how and why the nucleolus is targeted by different pathogenic organisms. Viruses are major organisms that disrupt the normal function of the nucleus and produce nucleoli proteins for facilitating the replication of viruses causing viral infections. In this review, we focus on the possible role of nucleoli upon coronavirus infections, particularly in coronavirus disease 2019. © 2022.
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