The Therapeutic Potential of Exosome Therapy in Sepsis Management: Addressing Complications and Improving Outcomes” Publisher Pubmed



Alikhiavi P¹ ; Mohammadi M² ; Masoumi S³ ; Saffarfar H⁴ ; Kheradmand R⁵ ; Mobed A⁵ ; Hatefnia F⁵ Show Affiliations
Source: Cell Biochemistry and Biophysics Published:2025

Abstract

Infection occurs when pathogens penetrate tissues, reproduce, and trigger a host response to both the infectious agents and their toxins. A diverse array of pathogens, including viruses and bacteria, can cause infections. The host’s immune system employs several mechanisms to combat these infections, typically involving an innate inflammatory response. Inflammation is a complex biological reaction that can affect various parts of the body and is a key component of the response to harmful stimuli. Sepsis arises when the body’s response to infection leads to widespread damage to tissues and organs, potentially resulting in severe outcomes or death. The initial phase of sepsis involves immune system suppression. Early identification and targeted management are crucial for improving sepsis outcomes. Common treatment approaches include antibiotics, intravenous fluids, blood cultures, and monitoring urine output. This study explores the potential of exosome therapy in enhancing the management and alleviation of sepsis symptoms. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.