Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Outer Membrane Vesicles in Gram-Negative Bacteria and Its Correlation With Pathogenesis Publisher Pubmed



Abolhasani FS1 ; Vaghefinanekaran N2 ; Yarahmadi A3 ; Akrami S4 ; Mirmahdavi S5, 6 ; Yousefi MH7, 8, 9 ; Afkhami H7, 9, 10, 11 ; Shafiei M12
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Microbiology, North Tehran Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Biology, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran
  4. 4. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Microbiology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  7. 7. Student Research Committee, Qom University of Medical Sciences, Qom, Iran
  8. 8. Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Qom University of Medical Sciences, Qom, Iran
  9. 9. Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran
  10. 10. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
  11. 11. Department of Medical Microbiology, School of Medicine, Shahed University, Tehran, Iran
  12. 12. Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran

Source: Frontiers in Immunology Published:2025


Abstract

There is a widespread distribution of gram-negative bacteria worldwide, which are responsible for the deaths of numerous patients each year. The illnesses they cause can be localized and systemic, and these bacteria possess several key virulence factors that contribute to their pathogenicity. In recent years, several distinct mechanisms of pathogenesis have evolved that remain largely unknown to scientists and medical experts. Among these, outer membrane vesicles (OMVs) are undoubtedly one of the most significant factors influencing virulence. OMVs contain various bacterial compounds and can have diverse effects on host organisms and the immune system, potentially exacerbating disease and inflammation while evading immune responses. This review comprehensively examines the role of OMVs in bacterial pathogenesis, their interaction with host cells, and their potential biomedical applications. Understanding the molecular mechanisms governing OMV biogenesis and function could pave the way for novel antimicrobial strategies and therapeutic interventions. Copyright © 2025 Abolhasani, Vaghefinanekaran, Yarahmadi, Akrami, Mirmahdavi, Yousefi, Afkhami and Shafiei.
Related Docs
View other Related Docs
1. Emerging Role of Microbiota Derived Outer Membrane Vesicles to Preventive, Therapeutic and Diagnostic Proposes, Infectious Agents and Cancer (2023)
2. Extracellular Vesicles Derived From Gastrointestinal Microbiota: A New Approach to Clinical Studies, Journal of Mazandaran University of Medical Sciences (2021)
3. Intestinal Effect of the Probiotic Escherichia Coli Strain Nissle 1917 and Its Omv, Journal of Diabetes and Metabolic Disorders (2020)
4. Commensal and Pathogenic Bacterial-Derived Extracellular Vesicles in Host-Bacterial and Interbacterial Dialogues: Two Sides of the Same Coin, Journal of Immunology Research (2022)
5. The Potential Use of Bacteria and Their Derivatives As Delivery Systems for Nanoparticles in the Treatment of Cancer, Journal of Drug Targeting (2025)
6. The Therapeutic Potential of Exosome Therapy in Sepsis Management: Addressing Complications and Improving Outcomes”, Cell Biochemistry and Biophysics (2025)
7. Mirnas in Outer Membrane Vesicles of Gut Microbiota: Friend or Foe?, Microbial Pathogenesis (2020)
8. Extraction and Evaluation of Outer Membrane Vesicles From Two Important Gut Microbiota Members, Bacteroides Fragilis and Bacteroides Thetaiotaomicron, Cell Journal (2020)
Experts (# of related papers)
View all Related Experts
Mojtaba Mojtahedzadeh (2)
Hanieh-Sadat Ejtahed (1)
Other Related Docs
9. Minimal Information for Studies of Extracellular Vesicles (Misev2023): From Basic to Advanced Approaches, Journal of Extracellular Vesicles (2024)
10. Microbiota-Derived Extracellular Vesicles As New Systemic Regulators, Frontiers in Microbiology (2017)
11. Construction and Assessment of the Immunogenicity and Bactericidal Activity of Fusion Protein Porin a From Neisseria Meningitidis Serogroups a and B Admixed With Omv Adjuvant As a Novel Vaccine Candidate, Iranian Journal of Basic Medical Sciences (2020)
12. Beyond Antibiotics: Exploring Multifaceted Approaches to Combat Bacterial Resistance in the Modern Era: A Comprehensive Review, Frontiers in Cellular and Infection Microbiology (2025)
13. Autophagy Induced by Helicobacter Pylori Infection Can Lead to Gastric Cancer Dormancy, Metastasis, and Recurrence: New Insights, Human Cell (2024)
14. The Effect of Probiotics on Immune Responses and Their Therapeutic Application: A New Treatment Option for Multiple Sclerosis, Biomedicine and Pharmacotherapy (2023)
15. The First Report of Bacteroides Fragilis and Bacteroides Thetaiotaomicron Relative Abundance in Obese Iranian Population, Jundishapur Journal of Natural Pharmaceutical Products (2022)
16. Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?, Biotechnology Advances (2018)
17. Lactobacillus Rhamnosus R0011 Treatment Enhanced Efficacy of Capecitabine Against Colon Cancer in Male Balb/C Mice, Nutrition and Cancer (2022)
18. Pseudomonas Aeruginosa Pao1 Outer Membrane Vesicles-Diphtheria Toxoid Conjugate As a Vaccine Candidate in a Murine Burn Model, Scientific Reports (2022)
19. Stimulatory Effects of Lactobacillus Casei Derived Extracellular Vesicles on Toll-Like Receptor 9 Gene Expression and Cytokine Profile in Human Intestinal Epithelial Cells, Journal of Diabetes and Metabolic Disorders (2020)
20. Microbial Metabolite Effects on Tlr to Develop Autoimmune Diseases, Toxin Reviews (2019)
21. Fusobacterium Nucleatum and Colorectal Cancer: A Mechanistic Overview, Journal of Cellular Physiology (2019)
22. The Regulation of Niemann-Pick C1-Like 1 (Npc1l1) Gene Expression in Opposite Direction by Bacteroides Spp. and Related Outer Membrane Vesicles in Caco-2 Cell Line, Journal of Diabetes and Metabolic Disorders (2020)