Determination of Association Between the Polymorphism in Exon 3 of Dopamine Receptor Gene Type 4 With Attention Deficit-Hyperactivity Disorder

Determination of Association Between the Polymorphism in Exon 3 of Dopamine Receptor Gene Type 4 With Attention Deficit-Hyperactivity Disorder Publisher

Effatpanah H¹ ; Effatpanah M² ; Mohammadi MJ³ ; Geravandi S¹ ; Ghadami M⁴ ; Ahmadkhaniha H⁵ ; Djavid GE⁶ ; Arabgol F⁷

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1. Department of Public Health, Asadabad School of Medical Sciences, Asadabad, Iran
2. School of Medicine, Ziaeian Hospital, International Campus, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Environmental Health Engineering, School of Public Health and Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4. Department of Medical Sciences, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Psychiatry, Faculty of Medicine, Iran University of Medical Sciences, Iran
6. Department of Microbiology, School of Biology, College of Sciences, University of Tehran, Tehran, Iran
7. Department of Psychiatry, Emam Hussein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Clinical Epidemiology and Global Health Published:2020

Abstract

Introduction: Evidences suggest that attention deficit-hyperactivity disorder (ADHD) is a hereditary disorder and at least 20 potential genes associated with ADHD have been identified. Dopamine receptor gene type 4 (DRD4) has been more considered due to a stronger relationship with ADHD. However, no study has yet been conducted on the Iranian population to assess the association. Objective: In this study, the association between polymorphism of DRD4 gene with ADHD has been studied among capital of Iran population. Materials and methods: This study is a case-control study conducted on children aged 6–12 years with ADHD referred to child and adolescent psychiatric clinic Imam Hussein (AS) and normal subjects in 2011. Diagnosis was done based on the DSM-IV-TR criteria and interviewing by two child and adolescent psychiatrists. If parental were consent, then saliva samples of subjects were prepared and DRD4 gene and related allele were evaluated using PCR method. The K-SADS questionnaire was also used to assess comorbid disorders. Results: In this study, 114 patients in ADHD group and 109 patients in the control group were studied. The most frequency was obtained for allele 4 allele that has been observed in about 90% of both case and control groups. However, frequency of allele 6 in the case group was 8.8% where the frequency was 5% in the control group (p = 0.02). The presence of repeat of allele 6 increased chance of suffering from ADHD to 1.809 (95% equal to 3.871–0.845). Conclusion: For the first time this study showed that in Iranian population repeat of DRD4 gene allele 6 unlike the other geographic areas is relatively common and it will increase the chances of suffering from ADHD. However, additional studies are required. © 2019

Style	Citing Format
MLA	Effatpanah H, et al.. "Determination of Association Between the Polymorphism in Exon 3 of Dopamine Receptor Gene Type 4 With Attention Deficit-Hyperactivity Disorder." Clinical Epidemiology and Global Health, vol. 8, no. 1, 2020, pp. 290-294.
APA	Effatpanah H, Effatpanah M, Mohammadi MJ, Geravandi S, Ghadami M, Ahmadkhaniha H, Djavid GE, Arabgol F (2020). Determination of Association Between the Polymorphism in Exon 3 of Dopamine Receptor Gene Type 4 With Attention Deficit-Hyperactivity Disorder. Clinical Epidemiology and Global Health, 8(1), 290-294.
Chicago	Effatpanah H, Effatpanah M, Mohammadi MJ, Geravandi S, Ghadami M, Ahmadkhaniha H, Djavid GE, Arabgol F. "Determination of Association Between the Polymorphism in Exon 3 of Dopamine Receptor Gene Type 4 With Attention Deficit-Hyperactivity Disorder." Clinical Epidemiology and Global Health 8, no. 1 (2020): 290-294.
Harvard	Effatpanah H et al. (2020) 'Determination of Association Between the Polymorphism in Exon 3 of Dopamine Receptor Gene Type 4 With Attention Deficit-Hyperactivity Disorder', Clinical Epidemiology and Global Health, 8(1), pp. 290-294.
Vancouver	Effatpanah H, Effatpanah M, Mohammadi MJ, Geravandi S, Ghadami M, Ahmadkhaniha H, et al.. Determination of Association Between the Polymorphism in Exon 3 of Dopamine Receptor Gene Type 4 With Attention Deficit-Hyperactivity Disorder. Clinical Epidemiology and Global Health. 2020;8(1):290-294.
BibTex	@article{ author = {Effatpanah H and Effatpanah M and Mohammadi MJ and Geravandi S and Ghadami M and Ahmadkhaniha H and Djavid GE and Arabgol F}, title = {Determination of Association Between the Polymorphism in Exon 3 of Dopamine Receptor Gene Type 4 With Attention Deficit-Hyperactivity Disorder}, journal = {Clinical Epidemiology and Global Health}, volume = {8}, number = {1}, pages = {290-294}, year = {2020} }
RIS	TY - JOUR AU - Effatpanah H AU - Effatpanah M AU - Mohammadi MJ AU - Geravandi S AU - Ghadami M AU - Ahmadkhaniha H AU - Djavid GE AU - Arabgol F TI - Determination of Association Between the Polymorphism in Exon 3 of Dopamine Receptor Gene Type 4 With Attention Deficit-Hyperactivity Disorder JO - Clinical Epidemiology and Global Health VL - 8 IS - 1 SP - 290 EP - 294 PY - 2020 ER -

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