Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Vdr Gene Polymorphisms Are Associated With the Increased Susceptibility to Covid-19 Among Iranian Population: A Case-Control Study Publisher Pubmed



Jafarpoor A1 ; Jazayeri SM1, 2 ; Bokharaeisalim F3 ; Ataeipirkooh A3 ; Ghaziasadi A1, 2 ; Soltani S1 ; Sadeghi A1, 4 ; Marvi SS1 ; Poortahmasebi V1, 5 ; Khorrami SMS6 ; Hasanzad M6, 7 ; Parsania N6 ; Nagozir S6 ; Mokhtari N6 Show All Authors
Authors
  1. Jafarpoor A1
  2. Jazayeri SM1, 2
  3. Bokharaeisalim F3
  4. Ataeipirkooh A3
  5. Ghaziasadi A1, 2
  6. Soltani S1
  7. Sadeghi A1, 4
  8. Marvi SS1
  9. Poortahmasebi V1, 5
  10. Khorrami SMS6
  11. Hasanzad M6, 7
  12. Parsania N6
  13. Nagozir S6
  14. Mokhtari N6
  15. Parsania A6
  16. Bahrami A6
  17. Nadjarha MH6
  18. Pakzad R8
  19. Parsania M1, 9
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Iranian Tissue Bank and Research Center, Tehran University of Medical Science, Tehran, Iran
  5. 5. Faculty of Medicine, Department of Bacteriology and Virology, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  7. 7. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Faculty of Health, Department of Epidemiology, Ilam University of Medical Sciences, Ilam, Iran
  9. 9. Faculty of Medicine, Department of Microbiology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: International Journal of Immunogenetics Published:2022


Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the pathogenesis is unclear. Host genetic background is one of the main factors influencing the patients' susceptibility to several viral infectious diseases. This study aimed to investigate the association between host genetic polymorphisms of two genes, including vitamin D receptor (VDR) and vitamin D binding protein (DBP), and susceptibility to COVID-19 in a sample of the Iranian population. This case-control study enrolled 188 hospitalized COVID-19 patients as the case group and 218 suspected COVID-19 patients with mild signs as the control group. The VDR (rs7975232, rs731236 and rs2228570) and DBP (rs7041) gene single nucleotide polymorphisms (SNPs) were genotyped by Polymerase Chain Reaction Restriction – Fragment Length Polymorphism (PCR-RFLP) method. A significant association between rs2228570 SNP in the VDR gene and the susceptibility of COVID-19 was found between case and control groups. The CT genotype (Heterozygous) of rs2228570 C > T polymorphism showed significant association with a 3.088 fold increased odds of COVID-19 (p <.0001; adjusted OR: 3.088; 95% CI: 1.902–5.012). In addition, a significant association between CC genotype of rs2228570 CT polymorphism and increased odds of COVID-19 in male and female groups (p =.001; adjusted OR: 3.125; 95% CI: 1.630–5.991 and p =.002; adjusted OR: 3.071; 95% CI: 1.485–6.354 respectively) were determined. Our results revealed no significant differences in the frequency of genotype and allele of VDR (rs7975232 and rs731236) and DBP (rs7041) between SARS-CoV-2-infected patients and controls (p >.05). Our results showed that polymorphism of VDR (rs2228570) probably could influence individual susceptibility to COVID-19. The polymorphisms of VDR (rs7975232 and rs731236) and DBP (rs7041) were not associated with SARS-CoV-2 infection susceptibility. © 2022 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Association of Vitamin D Receptor Gene Polymorphisms and Clinical/Severe Outcomes of Covid-19 Patients, Infection# Genetics and Evolution (2021)
2. Single Nucleotide Polymorphisms Located in Tnfa, Il1rn, Il6r, and Il6 Genes Are Associated With Covid-19 Risk and Severity in an Iranian Population, Cell Biology International (2022)
3. The Vitamin D Receptor Gene Variants, Apai, Taqi, Bsmi, and Foki in Diabetic Foot Ulcer and Their Association With Oxidative Stress, Molecular Biology Reports (2022)
4. Vitamin D Receptor Cdx-2-Dependent Response of Central Obesity to Vitamin D Intake in the Subjects With Type 2 Diabetes: A Randomised Clinical Trial, British Journal of Nutrition (2015)
5. Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy, Gene (2019)
6. Disease Severity in Respiratory Syncytial Virus Infection: Role of Host Genetic Variation, Reviews in Medical Virology (2019)
7. The Predictive Power of Serum Vitamin D for Poor Outcomes in Covid-19 Patients, Food Science and Nutrition (2021)
8. Vitamin D Receptor Gene Polymorphisms and Susceptibility to Type 2 Diabetes: Evidence From a Meta-Regression and Meta-Analysis Based on 47 Studies, Journal of Diabetes and Metabolic Disorders (2021)
Experts (# of related papers)
View all Related Experts
Afshin Ostovar (3)
Mahsa Mohamad Amoli (3)
Other Related Docs
9. A Comprehensive, Epidemiological and Ecological Descriptive Study on Vitamin D Status in Iran (308005 People, From 2009-2018), Iranian Journal of Public Health (2019)
10. Vitamin D Receptor Gene Polymorphism and Susceptibility to Asthma: Meta-Analysis Based on 17 Case-Control Studies, Annals of Allergy# Asthma and Immunology (2020)
11. The Prevalence of Vitamin D Deficiency, Its Predisposing Factors and Association With 24-Hour Urine Metabolites Among Iranian Kidney Stone Formers, Iranian Journal of Kidney Diseases (2021)
12. Prevalence of Vitamin D Deficiency and Its Associated Risk Factors Among Rural Population of the Northern Part of the Persian Gulf, BMC Endocrine Disorders (2021)
13. The Interplay Between Vitamin D and Viral Infections, Reviews in Medical Virology (2019)
14. Association of Tmprss2 Gene Polymorphisms With Covid-19 Severity and Mortality: A Case-Control Study With Computational Analyses, Applied Biochemistry and Biotechnology (2022)
15. Is There Any Association Between a Vitamin D Receptor Gene Polymorphism (Foki) and Pemphigus Vulgaris?, Iranian Journal of Dermatology (2020)
16. Vitamin D Effects on Immune Response Against Covid-19 and Influenza Infection: A Review, Bioactive Compounds in Health and Disease (2020)
17. Economic Evaluation of a National Vitamin D Supplementation Program Among Iranian Adolescents for the Prevention of Adulthood Type 2 Diabetes Mellitus, BMC Complementary Medicine and Therapies (2022)
18. Is Vitamin D Supplementation Program in Iranian Schools Effective in Reducing Adolescent Depressive Symptoms? Cost Effectiveness Study, BMC Public Health (2023)
19. Iranian Multicenter Osteoporosis Studies (Imos) During Last Decade: Rationale, Main Findings, Lessons Learned and the Way Forward, Journal of Diabetes and Metabolic Disorders (2020)
20. Vitamin D Deficiency in Children and Adolescents: Role of Puberty and Obesity on Vitamin D Status, Nutrition and Metabolic Insights (2021)
21. Association of Vdr Gene Polymorphisms With Risk of Relapsing-Remitting Multiple Sclerosis in an Iranian Kurdish Population, International Journal of Neuroscience (2018)
22. Vitamin D and Covid-19: From Potential Therapeutic Effects to Unanswered Questions, Reviews in Medical Virology (2021)
23. Vitamin D Supplementation and Risk of Hypercalciuria in Stone Formers, Iranian Journal of Kidney Diseases (2019)
24. Prevalence of Osteoporosis Among the Elderly Population of Iran, Archives of Osteoporosis (2021)
25. Enos Gene Glu298asp Variant Confer Risk in Sudden Sensorineural Hearing Loss, Acta Oto-Laryngologica (2018)
26. Reply To: A Key Role for Vitamin D Binding Protein in Covid-19?, European Journal of Nutrition (2021)