Epidermal Growth Factor Receptor (Egfr) Expression in High Grade Glioma and Relationship With Histopathologic Findings, a Cross Sectional Study Publisher



Miratashi Yazdi SA¹ ; Bakhshi N² ; Nazar E² ; Moradi Tabriz H² ; Gorji R³ Show Affiliations
Source: International Journal of Surgery Open Published:2022

Abstract

Introduction: There are some evidences for the relationship between the expression of epidermal growth factor receptor (EGFR) gene and the clinical and histopathological behavior of the high grade glioma. However, such a relationship can take quite different forms in different societies. We aimed to evaluate the EGFR expression status in high grade of glioma and its relationship with histopathological patterns in the tumor. Methods: We studied the immunohistochemichal expression of EGFR in 30 brain surgical resection specimens with different high grades. All samples were from pathology department of Sina Hospital in Tehran-Iran from 2020 to 2021. Results: EGFR positivity was reported in 56.6% of all tissue samples assessed. The assessment of relationship between EGFR expression and baseline and tumor characteristics showed no significant association of EGFR expression and patients’ gender, age, tumor location, tumor size, its type, grade, and also existence of necrosis (P value > 0.05). Conclusion: EGFR expression can be found in about half of our patients suffering high grade glioma. The over-expression of EGFR seems to be independent to demographic characteristics. Also, over-expression of EGFR may not predict the presence of necrosis in tumor tissue. © 2022