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Effects of Micrornas and Long Non-Coding Rnas on Chemotherapy Response in Glioma Publisher Pubmed



Ahmadpour S1 ; Taghavi T2 ; Sheida A3, 4 ; Tamehri Zadeh SS5 ; Hamblin MR6 ; Mirzaei H7
Authors
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Authors Affiliations
  1. 1. Department Of Biotechnology, Faculty Of Chemistry, University Of Kashan, Kashan, Iran
  2. 2. Department Of Cell & Moleclar Biology, University Of Tehran, Tehran, Iran
  3. 3. School Of Medicine, Kashan University Of Medical Sciences, Kashan, Iran
  4. 4. Student Research Committee, Kashan University Of Medical Sciences, Kashan, Iran
  5. 5. School Of Medicine, Tehran University Of Medical Sciences, Tehran, Iran
  6. 6. Laser Research Centre, Faculty Of Health Science, University Of Johannesburg, Doornfontein, 2028, South Africa
  7. 7. Research Center For Biochemistry & Nutrition In Metabolic Diseases, Institute For Basic Sciences, Kashan University Of Medical Sciences, Kashan, Iran

Source: Epigenomics Published:2022


Abstract

Glioma is the most prevalent invasive primary tumor of the central nervous system. Glioma cells can spread and infiltrate into normal surrounding brain tissues. Despite the standard use of chemotherapy and radiotherapy after surgery in glioma patients, treatment resistance is still a problem, as the underlying mechanisms are still not fully understood. Non-coding RNAs are widely involved in tumor progression and treatment resistance mechanisms. In the present review, we discuss the pathways by which microRNAs and long non-coding RNAs can affect resistance to chemotherapy and radiotherapy, as well as offer potential therapeutic options for future glioma treatment. © 2022 Future Medicine Ltd.
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