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Circular Rnas in Glioblastoma Publisher Pubmed



Ghadami E1 ; Jafari M2 ; Razipour M1 ; Maghsudlu M1 ; Ghadami M1, 3, 4
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iraq
  2. 2. Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iraq
  3. 3. Cardiac Primary Research Center, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iraq
  4. 4. Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iraq

Source: Clinica Chimica Acta Published:2025


Abstract

Glioblastoma multiforme (GBM) is the most malignant and common form of brain cancer in adults. The molecular mechanisms underlying GBM progression and resistance are complex and poorly understood. Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed loop structures with no free ends. Their circular structure makes them more stable than linear RNA and resistant to exonuclease degradation. In recent years, they have received significant attention due to their diverse functions in gene regulation and their association with various diseases, including cancer. Therefore, understanding the functions and applications of circRNAs is critical to developing targeted therapeutic interventions and advancing the field of glioblastoma cancer research. In this review, we summarized the main functions of circRNAs and their potential applications in the diagnosis, prognosis and targeted therapy of GBM. © 2024 Elsevier B.V.
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