Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Nps Loaded With Zoledronic Acid As an Advanced Tool for Cancer Therapy Publisher



Fathikarkan S1, 2 ; Zeeshan M3 ; Qindeel M4 ; Eshaghi Malekshah R5 ; Rahdar A6 ; Ferreira LFR7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Advanced Sciences and Technologies in Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 9414974877, Iran
  2. 2. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, 94531-55166, Iran
  3. 3. Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan
  4. 4. Faculty of Pharmacy, Hamdard university, Islamabad Campus, Islamabad, 45320, Pakistan
  5. 5. Medical Biomaterial Research Centre (MBRC), Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Physics, Faculty of Sciences, University of Zabol, Zabol, 538-98615, Iran
  7. 7. Programa de Pos-Graduacao em Ciencias Genomicas e Biotecnologia, Universidade Catolica de Brasilia, Brasilia, 71966-700, Brazil

Source: Journal of Drug Delivery Science and Technology Published:2023


Abstract

Zoledronic acid (ZA) has been shown to be beneficial against cancer both directly and indirectly. However, because of its fast absorption by bone, its use in extraskeletal malignancies has been limited. Due to its quick blood clearance, ZA is less effective as a cancer treatment. To utilize the numerous therapeutic properties of ZA, novel delivery strategies are necessary. While maintaining its pharmacological properties, nanomedicine is an excellent method of increasing ZA's circulatory half-life and intratumor accumulation. Nanoparticles (NPs) can enhance drug accumulation in neoplastic tissues by utilizing the increased permeability and retention effect (EPR) of fenestrations in tumor arteries. Loading the molecules inside the NP increases the solubility and stability of the drug and inhibits breakdown by serum proteins. Additionally, the release of the drug could be controlled, preventing early leakage. © 2023 Elsevier B.V.
Related Docs
1. Nanoparticles and Targeted Drug Delivery in Cancer Therapy, Immunology Letters (2017)
2. Microfluidic Synthesis of Zoledronic Acid Loaded Chitosan Nanoparticles Used for Osteogenic Differentiation of Mesenchymal Cells, International Journal of Biological Macromolecules (2023)
3. Emerging Innovations in Vincristine-Encapsulated Nanoparticles: Pioneering a New Era in Oncological Therapeutics, Journal of Drug Delivery Science and Technology (2024)
4. An Update on Actively Targeted Liposomes in Advanced Drug Delivery to Glioma, International Journal of Pharmaceutics (2021)
5. Cd133-Functionalized Gold Nanoparticles As a Carrier Platform for Telaglenastat (Cb-839) Against Tumor Stem Cells, International Journal of Molecular Sciences (2022)
6. Lipid-Based Nanoparticles for the Targeted Delivery of Anticancer Drugs: A Review, Current Drug Delivery (2022)
7. Nanofiber-Based Systems Against Skin Cancers: Therapeutic and Protective Approaches, Journal of Drug Delivery Science and Technology (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Akrami (1)
Mehdi Shafee Ardestani (1)