The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits

The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits Publisher

Ghoreishi SM¹ ; Najdian A² ; Yadegari S² ; Seyedhamzeh M² ; Etemadzade M³ ; Mirzaei M⁴ ; Hadadian S⁵ ; Alikhani Z⁶ ; Ardestani MS²

Show Affiliations

1. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Biology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
4. Iran Ministry of Health and Medical Education, Deputy Ministry for Education, Tehran, Iran
5. Nanobiotechnology Department, Pasteur Institute of Iran, Tehran, Iran
6. Department of Microbiology, Kerman Islamic Azad University, Kerman, Iran

Source: Contrast Media and Molecular Imaging Published:2020

Abstract

Even today, technetium-99m is a radionuclide choice for diagnostic in nuclear medicine. The unique chemical and physical properties of technetium-99m make it suitable as an available radionuclide in many centers. In this study, we examined the potential of CQD as a reducing agent in the MDP kit. Citric acid-derived CQD was synthesized and confirmed by FT-IR, TEM, UV-Vis, XPS, and surface analysis. No cytotoxicity was observed by the MTT assay. They were reducing properties of the CQD confirmed by fluorescence microscopy. The MDP kit is prepared by evaluating different parameters that affect the radiolabeling yield, including ligand, time, and CQD. The optimum amount of each parameter is obtained by Box-Behnken software. Finally, fluorescent spectroscopy, SPECT imaging, and biodistribution study showed that CQD reduces technetium-99m. Accumulation of radiotracer in the femur showed that CQD could be used in a radiopharmaceutical kit. © 2020 Seyedeh Masoumeh Ghoreishi et al.

Related Docs

View other Related Docs

1. Novel Manganese Carbon Quantum Dots As a Nano-Probe: Facile Synthesis, Characterization and Their Application in Naproxen Delivery (Mn/Cqd/Sio2@Naproxen), Bioorganic Chemistry (2021)

2. Synthesis and Characterization of Novel 99Mtc-Dgc Nano-Complexes for Improvement of Heart Diagnostic, Bioorganic Chemistry (2020)

3. Nanoparticles: Novel Vehicles in Treatment of Glioblastoma, Biomedicine and Pharmacotherapy (2016)

4. Recent Advances on the Application of Nanobiomimetic Structures As Drug Delivery Systems, Journal of Drug Delivery Science and Technology (2024)

5. Toxicity of Nanoparticles and an Overview of Current Experimental Models, Iranian Biomedical Journal (2016)

6. One-Step Synthesis of Silver Nanostructures Using Heracleum Persicum Fruit Extract, Their Cytotoxic Activity, Anti-Cancer and Anti-Oxidant Activities, Micro and Nano Letters (2023)

7. Targeting Neuroinflammation by Intranasal Delivery of Nanoparticles in Neurological Diseases: A Comprehensive Review, Naunyn-Schmiedeberg's Archives of Pharmacology (2022)

8. Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds, Frontiers in Chemistry (2022)

Experts (# of related papers)

View all Related Experts

Mehdi Shafee Ardestani (4)

Mahmoud Azami (1)

Style	Citing Format
MLA	Ghoreishi SM, et al.. "The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits." Contrast Media and Molecular Imaging, vol. 2020, no. , 2020, pp. -.
APA	Ghoreishi SM, Najdian A, Yadegari S, Seyedhamzeh M, Etemadzade M, Mirzaei M, Hadadian S, Alikhani Z, Ardestani MS (2020). The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits. Contrast Media and Molecular Imaging, 2020(), -.
Chicago	Ghoreishi SM, Najdian A, Yadegari S, Seyedhamzeh M, Etemadzade M, Mirzaei M, Hadadian S, Alikhani Z, Ardestani MS. "The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits." Contrast Media and Molecular Imaging 2020, no. (2020): -.
Harvard	Ghoreishi SM et al. (2020) 'The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits', Contrast Media and Molecular Imaging, 2020(), pp. -.
Vancouver	Ghoreishi SM, Najdian A, Yadegari S, Seyedhamzeh M, Etemadzade M, Mirzaei M, et al.. The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits. Contrast Media and Molecular Imaging. 2020;2020():-.
BibTex	@article{ author = {Ghoreishi SM and Najdian A and Yadegari S and Seyedhamzeh M and Etemadzade M and Mirzaei M and Hadadian S and Alikhani Z and Ardestani MS}, title = {The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits}, journal = {Contrast Media and Molecular Imaging}, volume = {2020}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Ghoreishi SM AU - Najdian A AU - Yadegari S AU - Seyedhamzeh M AU - Etemadzade M AU - Mirzaei M AU - Hadadian S AU - Alikhani Z AU - Ardestani MS TI - The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits JO - Contrast Media and Molecular Imaging VL - 2020 IS - SP - EP - PY - 2020 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract