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Application of Nanomedicine for Crossing the Blood–Brain Barrier: Theranostic Opportunities in Multiple Sclerosis Publisher Pubmed



Ghalamfarsa G1 ; Hojjatfarsangi M2, 3 ; Mohammadniaafrouzi M4 ; Anvari E5 ; Farhadi S6 ; Yousefi M7, 8 ; Jadidiniaragh F7, 8, 9
Authors
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Authors Affiliations
  1. 1. Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  2. 2. Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden
  3. 3. Department of Immunology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  4. 4. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  5. 5. Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  6. 6. Department of Agricultural Engineering, Islamic Azad University, Tehran, Iran
  7. 7. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Immunotoxicology Published:2016


Abstract

Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized with immunopathobiological events, including lymphocytic infiltration into the central nervous system (CNS), microglia activation, demyelination and axonal degeneration. Although several neuroprotective drugs have been designed for the treatment of MS, complete remission is yet matter of debate. Therefore, development of novel therapeutic approaches for MS is of a high priority in immunological research. Nanomedicine is a recently developed novel medical field, which is applicable in both diagnosis and treatment of several cancers and autoimmune diseases. Although there is a marked progress in neuroimaging through using nanoparticles, little is known regarding the therapeutic potential of nanomedicine in neurological disorders, particularly MS. Moreover, the majority of data is limited to the MS related animal models. In this review, we will discuss about the brain targeting potential of different nanoparticles as well as the role of nanomedicine in the diagnosis and treatment of MS and its animal model, experimental autoimmune encephalomyelitis. © 2016 Informa UK Limited trading as Taylor & Francis Group.
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