Molecular Mechanisms of Curcumins Suppressing Effects on Tumorigenesis, Angiogenesis and Metastasis, Focusing on Nf-Κb Pathway Publisher Pubmed



Panahi Y¹ ; Darvishi B^{2, 3, 4} ; Ghanei M¹ ; Jowzi N^{2, 3, 4} ; Beiraghdar F⁵ ; Varnamkhasti BS^{2, 3, 4}
Source: Cytokine and Growth Factor Reviews Published:2016

Abstract

NF-κB pathway has long been considered as one of the potent prototypical pro-inflammatory signaling pathway and its role in several aspects of human health has been established. Recent studies have suggested that NF-κB activation is the master key in early development and pathobiology of several Cancers. Curcumin is a polyphenolic phytochemical compound with several stablished anti-inflammatory properties and is known to exert its anti-inflammatory effects mostly by interrupting NF-κB signaling pathway at multiple stages. Here we tried to provide a summary of recent finding, focusing on introducing NF-κB signaling pathways and its potential mechanism involved in development of several types of Cancers. © 2015 Elsevier Ltd.