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Targeting Regulatory T Cells by Curcumin: A Potential for Cancer Immunotherapy Publisher Pubmed



Shafabakhsh R1 ; Pourhanifeh MH1 ; Mirzaei HR2 ; Sahebkar A3, 4, 5 ; Asemi Z1 ; Mirzaei H1
Authors
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Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Pharmacological Research Published:2019


Abstract

Immune system has critical roles in fighting against several diseases like cancer. Cancer cells evolve several ways to escape from the immune system to remain alive and trigger new phases of cancer progression. Regulatory T cells are one of the key components in tumor immune tolerance and contribute to the evasion of cancer cells from the immune system. Targeting regulatory T cells could provide new horizons in designing and development of effective therapeutic platforms for the treatment of various malignancies. Curcumin is the bioactive pigment of turmeric and a well-known phytochemical with a wide range of pharmacological activities. A growing body of evidence has demonstrated that curcumin affects manifold molecular pathways that are implicated in tumorigenesis and cancer metastasis. In this regard, some studies have indicated that this phytochemical could target regulatory T cells and convert them into T helper 1 cells, which possess anti-tumor effects. On the contrary, curcumin is able to increase the number of regulatory T cells in other conditions such as inflammatory bowel disease. Herein, we describe the anti-cancer roles of curcumin via targeting regulatory T cells. Moreover, we summarize the effects of curcumin on regulatory T cell population in other diseases. © 2019 Elsevier Ltd
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