Tehran University of Medical Sciences

Science Communicator Platform

Share By
Development of Herbal-Loaded Chitosan / Polyethylene Oxide Nanofiber Wound Dressing: Antibacterial Potential of Chamomile Extract Publisher



Nafei P ; Mohammadi Z ; Rastegari A ; Samadi N
Authors

Source: Indian Drugs Published:2025


Abstract

The use of chitosan nanofiber to accelerate wound healing has received great attention in recent years. Chamomile extract shows anti-inflammatory and antibacterial effects. In this study, solutions of chitosan and polyethylene oxide were prepared with different ratios and nanofibers are prepared by electrospinning method. After evaluation of prepared nanofibers by electron microscopy, ratio 80: 20 was selected for electrospinning of chamomile extract with different concentrations. The physicochemical characteristics of nanofibers and their antibacterial activity were investigated on Staphylococcus aureus and Pseudomonas aeruginosa. Obtained results showed release rate of extract and degradability of nanofibers to have increased with increasing extract concentration. Antibacterial results showed nanofiber containing 20%, 25% and 30% of chamomile extract could significantly reduce more than 4 logarithmic cycles after 2 h incubation. In conclusion, formulated nanofiber loaded by chamomile extract can be considered as a potential wound dressing with antibacterial property. © 2025, Indian Drug Manufacturers' Association. All rights reserved.
Related Docs
View other Related Docs
1. An Investigation of Electrospun Henna Leaves Extract-Loaded Chitosan Based Nanofibrous Mats for Skin Tissue Engineering, Materials Science and Engineering C (2017)
2. Production of Wound Dressing With Nano Fibers Contain Bassorin/ Ofloxacin for Improvement Burn Wound, Nanomedicine Research Journal (2018)
3. Exploring the Potential of a Polyvinyl Alcohol/Chitosan-Based Nanofibrous Matrix for Erythromycin Delivery: Fabrication, in Vitro and in Vivo Evaluation, RSC Advances (2023)
Experts (# of related papers)
View all Related Experts
Abbas Bahador (4)
Rassoul Dinarvand (2)
Other Related Docs
4. Assessing the Efficacy of Polyvinyl Alcohol/Chitosan Nanofibrous Mat Loaded With Myrtle Essential Oil/Gum Arabic in Wound Healing, Journal of Biomaterials Science, Polymer Edition (2025)
5. Producing Ofloxacin Loaded Gum Tragacanth/Bassorin Electrospun Nano Fibers and Evaluation Its Antibacterial Activity, Ekoloji (2019)
6. Development of Pva/Chitosan-G-Poly (N-Vinyl Imidazole)/Tio2/Curcumin Nanofibers As High-Performance Wound Dressing, Carbohydrate Polymers (2022)
7. Preparation of Polyurethane/Pluronic F127 Nanofibers Containing Peppermint Extract Loaded Gelatin Nanoparticles for Diabetic Wounds Healing: Characterization, in Vitro, and in Vivo Studies, Evidence-based Complementary and Alternative Medicine (2021)
8. Preparation, Antioxidant, Antibacterial, and in Vivo Evaluation of Pomegranate Flower Extract Nanofibers Based on Thiolated Chitosan and Thiolated Gelatin for Treating Aphthous Stomatitis, Carbohydrate Polymers (2025)
9. Promising Antibacterial Activity of a Mat of Polycaprolactone Nanofibers Impregnated With a Green Nanogel, Nanomedicine Research Journal (2020)
10. Chitosan/Pva Nanofiber for the Application in Implantable Drug Delivery Systems, Nanomedicine Research Journal (2022)
11. Novel Pla/Zno Nanofibrous Nanocomposite Loaded With Tranexamic Acid As an Effective Wound Dressing: In Vitro and in Vivo Assessment, Iranian Journal of Biotechnology (2021)
12. Metformin and Silymarin Loaded Onto Poly(Caprolactone)/Chitosan Polymeric Nanofiber Based Pads for Diabetic Wound Healing, New Journal of Chemistry (2024)
13. Co-Electrospun Pcl-Collagen Nanofibers Containing Saffron-Synthesized Gold Nanoparticles As an Antioxidant Wound Dressing, Proceedings of the Institution of Mechanical Engineers# Part H: Journal of Engineering in Medicine (2023)
14. Polyhexamethylene Biguanidine Coated Silver Nanoparticles Embedded Into Chitosan Thiourea/Pva Nanofibers As Wound Healing Mats: In Vitro and in Vivo Studies, Carbohydrate Polymers (2025)
15. L. Inermis-Loaded Nanofibrous Scaffolds for Wound Dressing Applications, Tissue and Cell (2018)
16. Levofloxacin Loaded Poly (Ethylene Oxide)-Chitosan/Quercetin Loaded Poly (D,L-Lactide-Co-Glycolide) Core-Shell Electrospun Nanofibers for Burn Wound Healing, Frontiers in Bioengineering and Biotechnology (2024)
17. Predictive Modeling of Phenolic Compound Release From Nanofibers of Electrospun Networks for Application in Periodontal Disease, Journal of Polymer Engineering (2016)
18. Crosslinked-Polyvinyl Alcohol-Carboxymethyl Cellulose/Zno Nanocomposite Fibrous Mats Containing Erythromycin (Pva-Cmc/Zno-Em): Fabrication, Characterization and In-Vitro Release and Anti-Bacterial Properties, International Journal of Biological Macromolecules (2019)