Production of Wound Dressing With Nano Fibers Contain Bassorin/ Ofloxacin for Improvement Burn Wound Publisher



Morad FN¹ ; Rashid A¹ ; Khajavi R² ; Rahimi MK^{2, 3} ; Bahador A⁴ Show Affiliations
Source: Nanomedicine Research Journal Published:2018

Abstract

Gum Tragacanth (GT) obtained from Astragalus Gossypinus is one of the most widely used natural gums which has found applications in many zone because of its appealing features such as biodegradability, nonpoisonous nature, natural accessibility, moisture absorption and creating a network of Hydrocolloid. It also has maintenance and delivery of drugs, higher resistance movement to bacterial attacks and lengthy shelf-life properties. In present study, preparation nanofibers of 50 wt% Bassorin (extracted from Gum Tragacanth) has been mixed by 50 wt% Poly Ethylene Oxide and 0.01 wt% Ofloxacin (Ba/PEO/Ofx) for Electrospinning. Nanofibers coated on cotton gauze. The properties of Bassorin and produced nanofibers were examined via XRD, FTIR and SEM microscopy. The Antibacterial of nanofibers activity against Staphylococcus aureus as gram positive bacteria and Escherichia coli as a gram-negative bacteria also were studied. Nanofibers are able of absorbing wound’s exocrine liquid easily due to their high specific area of nano fibers which 4 to 5% more than cotton gauzes without nanofibers. When it is conversion to gel by moisture sorption, the release of loaded Ofloxacin would be increased. The Antibacterial assay showed the cotton gauze coated with Ba/PEO/Ofx nanofibers could inhibit about 90% growth both bacterial strain on burn wound. Also, the therapeutic effect of nano-bassorin in restoring superficial second-degree burns in rats showed an accelerated effect on wound healing. Based on the results of this study, it is possible to use cotton gauzes coated with bassorin nanofibers as a suitable candidate for the treatment of second-degree superficial burns. © 2018 Tehran University of Medical Sciences. All rights reserved.