Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Limitations in Clinical Translation of Nanoparticle-Based Gene Therapy Publisher Pubmed



Wong JKL1 ; Mohseni R2 ; Hamidieh AA2 ; Maclaren RE3 ; Habib N4 ; Seifalian AM5
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Imperial College London, London, United Kingdom
  2. 2. Hematology–Oncology and Stem Cell Transplantation Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
  4. 4. Faculty of Medicine, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
  5. 5. Nanotechnology and Regenerative Medicine Centre (Ltd), The London BioScience Innovation Centre, London, United Kingdom

Source: Trends in Biotechnology Published:2017


Abstract

Organic nanoparticle-based (ONP) gene therapy is a potential strategy to cure human cancer. However, there are still many practical barriers before the promising results from in vitro and preclinical studies can be translated to clinical success. We discuss the reasons behind the hesitant uptake by the clinic. © 2017 Elsevier Ltd