Il-33/St2 Axis in Autoimmune Disease

Il-33/St2 Axis in Autoimmune Disease Publisher Pubmed

Shakerian L¹ ; Kolahdooz H² ; Garousi M³ ; Keyvani V⁴ ; Kamal Kheder R^{5, 6} ; Abdulsattar Faraj T^{6, 7} ; Yazdanpanah E^{2, 8} ; Esmaeili SA^{2, 8}

Show Affiliations

1. Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3. Department of Internal Medicine, Faculty of Medical Sciences, Hamedan University of Medical Sciences, Hamedan, Iran
4. Molecular Genetics, Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
5. Medical Laboratory Science Department, College of Science, University of Raparin, Rania 46012, Sulaymaniyah, Iraq
6. Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq
7. Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil, Iraq
8. Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Cytokine Published:2022

Abstract

Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in mast cells, basophils, eosinophils, NK cells, and T lymphocyte cells. The vital role of IL-33 as an active component gives rise to aberrant local and systemic damage which has been demonstrated in numerous inflammatory disorders and immune-mediated pathological conditions including multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, Sjogren's syndrome, inflammatory bowel disease (IBD), etc. IL-33/ST2 axis can up-regulate pro-inflammatory cytokine release in autoimmune disease, however, in some metabolic diseases like diabetes mellitus type 1 IL-33 can be considered an anti-inflammatory cytokine. The purpose of this review is to discuss selected studies on IL-33/ST2 axis in autoimmune diseases and its potential role as a pathogenic or protective cytokine. © 2022

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Style	Citing Format
MLA	Shakerian L, et al.. "Il-33/St2 Axis in Autoimmune Disease." Cytokine, vol. 158, no. , 2022, pp. -.
APA	Shakerian L, Kolahdooz H, Garousi M, Keyvani V, Kamal Kheder R, Abdulsattar Faraj T, Yazdanpanah E, Esmaeili SA (2022). Il-33/St2 Axis in Autoimmune Disease. Cytokine, 158(), -.
Chicago	Shakerian L, Kolahdooz H, Garousi M, Keyvani V, Kamal Kheder R, Abdulsattar Faraj T, Yazdanpanah E, Esmaeili SA. "Il-33/St2 Axis in Autoimmune Disease." Cytokine 158, no. (2022): -.
Harvard	Shakerian L et al. (2022) 'Il-33/St2 Axis in Autoimmune Disease', Cytokine, 158(), pp. -.
Vancouver	Shakerian L, Kolahdooz H, Garousi M, Keyvani V, Kamal Kheder R, Abdulsattar Faraj T, et al.. Il-33/St2 Axis in Autoimmune Disease. Cytokine. 2022;158():-.
BibTex	@article{ author = {Shakerian L and Kolahdooz H and Garousi M and Keyvani V and Kamal Kheder R and Abdulsattar Faraj T and Yazdanpanah E and Esmaeili SA}, title = {Il-33/St2 Axis in Autoimmune Disease}, journal = {Cytokine}, volume = {158}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Shakerian L AU - Kolahdooz H AU - Garousi M AU - Keyvani V AU - Kamal Kheder R AU - Abdulsattar Faraj T AU - Yazdanpanah E AU - Esmaeili SA TI - Il-33/St2 Axis in Autoimmune Disease JO - Cytokine VL - 158 IS - SP - EP - PY - 2022 ER -

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