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The Role of the Il-33/St2 Immune Pathway in Autoimmunity: New Insights and Perspectives Publisher Pubmed



Ramezani F1 ; Babaie F2 ; Aslani S3 ; Hemmatzadeh M4, 5 ; Mohammadi FS6 ; Gowharishabgah A7 ; Jadidiniaragh F5, 8 ; Ezzatifar F9, 10 ; Mohammadi H11, 12
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Department of Immunology and Genetic, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  3. 3. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Immunology Research Center, Inflammation and Inflammatory Diseases Division, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. School of Medicine, Bam University of Medical Sciences, Bam, Iran
  8. 8. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Molecular and Cell Biology Research Center, Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  10. 10. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  11. 11. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  12. 12. Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Source: Immunological Investigations Published:2022


Abstract

Interleukin (IL)-33, a member of IL-1 cytokine family, is produced by various immune cells and acts as an alarm to alert the immune system after epithelial or endothelial cell damage during cell necrosis, infection, stress, and trauma. The biological functions of IL-33 largely depend on its ligation to the corresponding receptor, suppression of tumorigenicity 2 (ST2). The pathogenic roles of this cytokine have been implicated in several disorders, including allergic disease, cardiovascular disease, autoimmune disease, infectious disease, and cancers. However, alerted levels of IL-33 may result in either disease amelioration or progression. Genetic variations of IL33 gene may confer protective or susceptibility risk in the onset of autoimmune diseases. The purpose of this review is to discuss the involvement of IL-33 and ST2 in the pathogenesis of a variety of autoimmune disorders, such as autoimmune rheumatic, neurodegenerative, and endocrine diseases. © 2021 Taylor & Francis Group, LLC.
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