Biomarkers of Il-33 and Sst2 and Lack of Association With Carvedilol Therapy in Heart Failure Publisher



Firouzabadi N^{1, 2, 3} ; Dashti M¹ ; Dehshahri A⁴ ; Bahramali E⁵ Show Affiliations
Source: Clinical Pharmacology: Advances and Applications Published:2020

Abstract

Objective: The IL-33/ST2 pathway plays a fundamental role in the cardiovascular system and can be considered as a new therapeutic strategy for the treatment or prevention of cardiovascular diseases. ST2, as an interleukin (IL)-1 receptor family member, has trans-membrane (ST2L) and soluble (sST2) isoforms. sST2 neutralizes IL-33 and thereby inhibits the cardioprotective role of IL-33/ST2L signaling pathway. Increase in sST2 level is associated with weak cardiac output and can be a predictor of mortality in heart failure (HF).; Thereby, we hypothesized that there may be a relationship between the cardioprotective, effects of carvedilol and sST2 and IL-3 in HF patients. Methods: sST2 and IL-33 were measured in serum of 66 individuals; 22 healthy volunteers l and 44 suffering from HF; among whom 25 patients received carvedilol and the other 19 patients did not receive any β-blockers.; Results: Lack of association between serum levels of IL-33 and sST2 was observed between HF patients and healthy individuals (2.4466 ± 0.69 vs 2.6748 ± 0.33 and 3416.6 ± 1089.1 vs 2971.6 ± 792.5, respectively). Our results indicated no significant difference between sST2 and IL-33 levels in HF patients who did not receive beta-blockers and patients receiving carvedilol (P=0.59 and P=0.97). Conclusion: Our results showed a lack of association between serum levels of IL-33 and sST2 and HF. Moreover, the results do not confirm the cardioprotective mechanism of carvedilol by means of IL-33/sST2 pathway. © 2020 Firouzabadi et al.