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Importance of Dual Delivery Systems for Bone Tissue Engineering Publisher Pubmed



Farokhi M1 ; Mottaghitalab F2 ; Shokrgozar MA1 ; Ou KL3, 4 ; Mao C5 ; Hosseinkhani H6
Authors
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Authors Affiliations
  1. 1. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, Taiwan
  4. 4. Department of Dentistry, Taipei Medical University - Shuang Ho Hospital, New Taipei city, Taiwan
  5. 5. Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, 73019, OK, United States
  6. 6. Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan

Source: Journal of Controlled Release Published:2016


Abstract

Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering. © 2015 Elsevier B.V. All rights reserved.
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