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Relationship Between Antifungal Susceptibility Profile and Virulence Factors in Candida Albicanisolated From Nail Specimens Publisher Pubmed



Mohammadi F1 ; Ghasemi Z2 ; Familsatarian B3 ; Salehi E2 ; Sharifynia S4 ; Barikani A5 ; Mirzadeh M6 ; Hosseini MA7
Authors
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Authors Affiliations
  1. 1. Medical Microbiology Research Center, Qazvin university of Medical Science, Qazvin, Iran
  2. 2. Medical Mycology of Razi Hospital, Tehran, Iran
  3. 3. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
  4. 4. Clinical Tuberculosis and Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Children Growth Research Center, Qazvin University of Medical Science, Qazvin, Iran
  6. 6. Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
  7. 7. Qazvin University of Medical Sciences, Qazvin, Iran

Source: Revista da Sociedade Brasileira de Medicina Tropical Published:2020


Abstract

Introduction: The aim of this study was to evaluate some virulence factors in Candida albicans isolates from patients with onychomycosis and determine the correlation between these factors and the antifungal resistance profile. Methods: Seventy species of C. albicans were confirmed using polymerase chain reaction amplification of the HWP1 gene. According to the Clinical & Laboratory Standards Institute guidelines, the susceptibility profile of four antifungal agents was investigated, and the production of aspartyl protease, phospholipase, haemolysin, and biofilm was determined. The correlation between these profiles was also investigated. Results: The isolates indicated different levels of resistance and production of virulence factors. Significant correlations were observed between the minimum inhibitory concentration (MIC) of fluconazole/itraconazole and biofilm production, between phospholipase production and fluconazole/ itraconazole MIC, and between fluconazole MIC and hemolytic activity in C. albicans isolates. The results also showed significant correlations between phospholipase activity and biofilm production. Conclusions: Our findings will contribute to a better understanding of the pathogenesis of C. albicans and characterize the relationship between virulence factors and antifungal resistance, which may suggest new therapeutic strategies considering the possible involvement of the virulence mechanism in the effectiveness of treatment. © 2020, Sociedade Brasileira de Medicina Tropical. All rights reserved.
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