Autophagy Pathways in Major Depressive Disorder

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G Shafiei GOLNAZ ; M Saadat MARYAM ; S Farajpour SHIMA ; Sh Mohammadi Shima H ; N Dashti NASRIN ; T Mokhtari TAHMINEH

Source: Published:2025

Abstract

Major depressive disorder (MDD) is a chronic condition with high prevalence, especially in individuals with physical illnesses. This chapter explores autophagy's involvement in MDD, connecting it to oxidative stress, increased pro- inflammatory cytokine levels, and impaired mitochondrial function. Dysregulated autophagy contributes to MDD pathophysiology, offering insights into novel therapeutic strategies. The authors review preclinical and clinical evidence, the effects of conventional antidepressants on autophagy, and the potential of herbal products in modulating these pathways. Understanding autophagy's role in MDD underscores the need for further research to develop targeted treatments. © 2025 Elsevier B.V., All rights reserved.

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Style	Citing Format
MLA	G Shafiei GOLNAZ, et al.. "Autophagy Pathways in Major Depressive Disorder." , vol. , no. , 2025, pp. 125-162.
APA	G Shafiei GOLNAZ, M Saadat MARYAM, S Farajpour SHIMA, Sh Mohammadi Shima H, N Dashti NASRIN, T Mokhtari TAHMINEH (2025). Autophagy Pathways in Major Depressive Disorder. , (), 125-162.
Chicago	G Shafiei GOLNAZ, M Saadat MARYAM, S Farajpour SHIMA, Sh Mohammadi Shima H, N Dashti NASRIN, T Mokhtari TAHMINEH. "Autophagy Pathways in Major Depressive Disorder." , no. (2025): 125-162.
Harvard	G Shafiei GOLNAZ et al. (2025) 'Autophagy Pathways in Major Depressive Disorder', , (), pp. 125-162.
Vancouver	G Shafiei GOLNAZ, M Saadat MARYAM, S Farajpour SHIMA, Sh Mohammadi Shima H, N Dashti NASRIN, T Mokhtari TAHMINEH. Autophagy Pathways in Major Depressive Disorder. . 2025;():125-162.
BibTex	@article{ author = {G Shafiei GOLNAZ and M Saadat MARYAM and S Farajpour SHIMA and Sh Mohammadi Shima H and N Dashti NASRIN and T Mokhtari TAHMINEH}, title = {Autophagy Pathways in Major Depressive Disorder}, journal = {}, volume = {}, number = {}, pages = {125-162}, year = {2025} }
RIS	TY - JOUR AU - G Shafiei GOLNAZ AU - M Saadat MARYAM AU - S Farajpour SHIMA AU - Sh Mohammadi Shima H AU - N Dashti NASRIN AU - T Mokhtari TAHMINEH TI - Autophagy Pathways in Major Depressive Disorder JO - VL - IS - SP - 125 EP - 162 PY - 2025 ER -

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