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Exosomes As Novel Tools for Renal Cell Carcinoma Therapy, Diagnosis, and Prognosis Publisher



Razavinia A1 ; Razavinia A1 ; Jamshidi Khalife Lou R1 ; Ghavami M3, 4 ; Shahri F5 ; Tafazoli A6 ; Khalesi B7 ; Hashemi ZS8 ; Khalili S9
Authors
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Authors Affiliations
  1. 1. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  2. 2. Genetics Department, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Pathology, Dalhousie University, Halifax, NS, Canada
  4. 4. Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada
  5. 5. Department of Chemistry, Faculty of Sciences, University of Guilan, Iran
  6. 6. Department of Bacterial and Virology, Shiraz medical school, Shiraz, Iran
  7. 7. Department of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, 3197619751, Iran
  8. 8. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  9. 9. Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran

Source: Heliyon Published:2024


Abstract

Background: Renal Cell Carcinoma (RCC) stands as a formidable challenge within the field of oncology, despite considerable research endeavors. The advanced stages of this malignancy present formidable barriers to effective treatment and management. Objective: This review aims to explore the potential of exosomes in addressing the diagnostic and therapeutic challenges associated with RCC. Specifically, it investigates the role of exosomes as biomarkers and therapeutic vehicles in the context of RCC management. Methods: For this review article, a comprehensive literature search was conducted using databases such as PubMed, employing relevant keywords to identify research articles pertinent to the objectives of the review. Initially, 200 articles were identified, which underwent screening to remove duplicates and assess relevance based on titles and abstracts, followed by a detailed examination of full texts. From the selected articles, relevant data were extracted and synthesized to address the review's objectives. The conclusions were drawn based on a thorough analysis of the findings. The quality was ensured through independent review and resolution of discrepancies among multiple reviewers. Results: Exosomes demonstrate potential as diagnostic tools for early detection, prognosis, and treatment monitoring in RCC. Their ability to deliver various therapeutic agents, such as small interfering RNAs, lncRNAs, chemotherapeutic drugs, and immune-stimulating agents, allows for a personalized approach to RCC management. By leveraging exosome-based technologies, precision and efficacy in treatment strategies can be significantly enhanced. Conclusion: Despite the promising advancements enabled by exosomes in the management of RCC, further research is necessary to refine exosome-based technologies and validate their efficacy, safety, and long-term benefits through rigorous clinical trials. Embracing exosomes as integral components of RCC diagnosis and treatment represents a significant step towards improving patient outcomes and addressing the persistent challenges posed by this malignancy in the field of oncology. © 2024 The Authors
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