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Circulating Mesenchymal Stem Cells in Sulfur Mustard-Exposed Patients With Long-Term Pulmonary Complications Publisher Pubmed



Ghazanfari T1, 2 ; Ghaffarpour S1 ; Kariminia A3 ; Salehi E4 ; Hashemi SM5 ; Ardestani SK6 ; Gohari Moghadam K7 ; Mirsharif ES1 ; Dilmaghanian R1 ; Fadaei A8 ; Faghihzadeh S9
Authors
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Authors Affiliations
  1. 1. Immunoregulation Research Center, Shahed University, Tehran, Iran
  2. 2. Department of Immunology, Shahed University, North Karegar Street, Tehran, 1471, Iran
  3. 3. British Columbia Children's Hospital Research Institute, Pediatrics Department, Faculty of, Medicine, University of British Columbia, Vancouver, BC, Canada
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Shahid Beheshti University of Medica, Sciences, Tehran, Iran
  6. 6. Institute of Biochemistry and Biophysics, Tehran University, Tehran, Iran
  7. 7. Internal Medicine Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Pulmonology and Intensive Care Medicine, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Toxicology Letters Published:2019


Abstract

Sulfur mustard (SM)is a toxic agent that causes acute and long-term pulmonary complications. Recent evidence has shown the impact of SM on mesenchymal stem cells (MSCs). These cells have a critical role in repairing the damaged tissues. In this study, we evaluated the mobilization of MSCs in SM-exposed patients with long-term pulmonary complications. Fifty-nine SM-injured patients with prolonged pulmonary complications and 20 healthy individuals were included. Patients were classified based on taking drugs, having comorbidities, and severity of respiratory consequence. MSCs with phenotype of CD45-CD44+CD29+CD105+ were evaluated in peripheral blood using flow cytometry. Circulating MSCs were lower in SM-exposed patients compared to the control group (0.93 vs. 2.72 respectively, P = 0.005). No significant difference was observed in the MSC count between patients taking corticosteroids or antibiotics and those patients not taking them. Comorbidities like liver and kidney diseases had changed the count of MSCs in SM-exposed subjects. In addition, the frequency of MSCs did not show any association with the severity of long-term pulmonary complications. In conclusion, SM-exposure causes a decline in the frequency of circulating MSCs in survivors. The lower number of the peripheral MSC population in SM-exposed patients was not affected by taking corticosteroids or antibiotics, but comorbidities are probably involved in MSC frequency. The decreases observed in the number of circulating MSCs was not associated with the severity of the pulmonary complications; however, further studies in mustard lung models are required to demonstrate the therapeutic or pathologic role of MSCs in SM injuries. © 2019 Elsevier B.V.
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