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Mitochondrial Haplogroups and Control Region Polymorphisms in Kaposi's Sarcoma Patients Publisher Pubmed



Jalilvand S1 ; Shoja Z2 ; Marashi SM1 ; Shahmahmoodi S1 ; Safaienaraghi Z3 ; Nourijelyani K4 ; Nesheli AB5 ; Mokhtariazad T1
Authors
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Authors Affiliations
  1. 1. Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Virology Department, Pasteur Institute of Iran, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Biostatistics Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Qazvin Blood Transfusion Center, Iran Blood Transfusion Organization Research Center, Qazvin, Iran

Source: Journal of Medical Virology Published:2015


Abstract

Inflammation and reactive oxygen species (ROS) production have recently considered as key mechanisms in the pathogenesis of Kaposi's sarcoma (KS). Since mitochondria are the major source of ROS production, this organelle may play a main role in KS development. However, there are no studies on mtDNA variations and haplogroups in this area. The focus of this study was to investigate the mtDNA variants and haplogroups in KS patients and their relationship to tumor development. To address this, we have genotyped mtDNA in 45 Iranian KS patients and 48 age and sex-matched Iranian controls. A strong positive correlation was observed between UK cluster and decreased risk of KS. Our results suggest that the UK cluster might be a protective haplogroup for KS development. It is probably superhaplogroup UK, with lower ATP and ROS production, may prevent KSHV reactivation from latent to lytic phase that is essential for KS development. © 2015 Wiley Periodicals, Inc.
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