The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells

The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells Publisher Pubmed

Hosseini R¹ ; Asefkabiri L² ; Yousefi H³ ; Sarvnaz H⁴ ; Salehi M⁵ ; Akbari ME² ; Eskandari N¹

Show Affiliations

1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, United States
4. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

Source: Molecular Cancer Published:2021

Abstract

Tumor-derived exosomes (TDEs) have been shown to impede anti-tumor immune responses via their immunosuppressive cargo. Since dendritic cells (DCs) are the key mediators of priming and maintenance of T cell-mediated responses; thus it is logical that the exosomes released by tumor cells can exert a dominant influence on DCs biology. This paper intends to provide a mechanistic insight into the TDEs-mediated DCs abnormalities in the tumor context. More importantly, we discuss extensively how tumor exosomes induce subversion of DCs differentiation, maturation and function in separate sections. We also briefly describe the importance of TDEs at therapeutic level to help guide future treatment options, in particular DC-based vaccination strategy, and review advances in the design and discovery of exosome inhibitors. Understanding the exosomal content and the pathways by which TDEs are responsible for immune evasion may help to revise treatment rationales and devise novel therapeutic approaches to overcome the hurdles in cancer treatment. © 2021, The Author(s).

Related Docs

View other Related Docs

1. Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy, Molecular Cancer (2022)

2. Harnessing the Power of Exosomes for Diagnosis, Prognosis, and Treatment of Hematological Malignancies, Stem Cell Research and Therapy (2025)

3. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)

4. Tumor-Derived Exosomes: The Next Generation of Promising Cell-Free Vaccines in Cancer Immunotherapy, OncoImmunology (2020)

5. Modifying Exosome Release in Cancer Therapy: How Can It Help?, Pharmacological Research (2018)

6. Exosomes and Cancer, Synthesis Lectures on Biomedical Engineering (2022)

7. Current Understanding of the Exosomes and Their Associated Biomolecules in the Glioblastoma Biology, Clinical Treatment, and Diagnosis, Journal of Neuroimmune Pharmacology (2025)

8. Blockade of Exosome Release Alters Her2 Trafficking to the Plasma Membrane and Gives a Boost to Trastuzumab, Clinical and Translational Oncology (2023)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (10)

Hamid Reza Mirzaei (7)

Style	Citing Format
MLA	Hosseini R, et al.. "The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells." Molecular Cancer, vol. 20, no. 1, 2021, pp. -.
APA	Hosseini R, Asefkabiri L, Yousefi H, Sarvnaz H, Salehi M, Akbari ME, Eskandari N (2021). The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells. Molecular Cancer, 20(1), -.
Chicago	Hosseini R, Asefkabiri L, Yousefi H, Sarvnaz H, Salehi M, Akbari ME, Eskandari N. "The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells." Molecular Cancer 20, no. 1 (2021): -.
Harvard	Hosseini R et al. (2021) 'The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells', Molecular Cancer, 20(1), pp. -.
Vancouver	Hosseini R, Asefkabiri L, Yousefi H, Sarvnaz H, Salehi M, Akbari ME, et al.. The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells. Molecular Cancer. 2021;20(1):-.
BibTex	@article{ author = {Hosseini R and Asefkabiri L and Yousefi H and Sarvnaz H and Salehi M and Akbari ME and Eskandari N}, title = {The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells}, journal = {Molecular Cancer}, volume = {20}, number = {1}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Hosseini R AU - Asefkabiri L AU - Yousefi H AU - Sarvnaz H AU - Salehi M AU - Akbari ME AU - Eskandari N TI - The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells JO - Molecular Cancer VL - 20 IS - 1 SP - EP - PY - 2021 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract