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Trends of National and Sub-National Burden Attributed to Kidney Dysfunction Risk Factor in Iran: 1990-2019 Publisher



Nejadghaderi SA1, 2 ; Moghaddam SS1, 3 ; Keykhaei M1 ; Shobeiri P4, 5 ; Rezaei N1, 6 ; Rezaei N1, 6 ; Naghavi M7, 8 ; Larijani B6 ; Farzadfar F1, 6 ; Abdollahi A9, 10 ; Ahmadi A11, 12 ; Ahmadi S13 ; Alatab S14 ; Arabloo J15 Show All Authors
Authors
  1. Nejadghaderi SA1, 2
  2. Moghaddam SS1, 3
  3. Keykhaei M1
  4. Shobeiri P4, 5
  5. Rezaei N1, 6
  6. Rezaei N1, 6
  7. Naghavi M7, 8
  8. Larijani B6
  9. Farzadfar F1, 6
  10. Abdollahi A9, 10
  11. Ahmadi A11, 12
  12. Ahmadi S13
  13. Alatab S14
  14. Arabloo J15
  15. Arjomandzadegan M16
  16. Athari SS17
  17. Azadnajafabad S1
  18. Azangoukhyavy M1, 18
  19. Baghcheghi N19
  20. Bagherieh S20
  21. Barati S21
  22. Dehghan A22
  23. Fatehizadeh A23
  24. Ghadirian F24
  25. Gholamalizadeh M25
  26. Gholami A26, 27
  27. Gohari K1, 28
  28. Hassankhani H29, 30
  29. Jokar M31, 32
  30. Khorashadizadeh F26
  31. Kompani F33
  32. Koohestani HR34
  33. Mahjoub S35, 36
  34. Mahmoodpoor A37
  35. Rad EM38
  36. Mobayen M39
  37. Mohammadi E1, 40
  38. Moradi Y41
  39. Morovatdar N42
  40. Noori M43
  41. Okatialiabad H44
  42. Pourali G45, 46
  43. Rafferty Q7
  44. Rashedi S1, 47
  45. Rashidi M48
  46. Rashidi MM1, 18
  47. Sahebkar A49, 50
  48. Shorofi SA51, 52
  49. Tabatabaei SM42, 53
  50. Taheri M54, 55
  51. Taherkhani A56
  52. Zahir M57
  53. Zangiabadian M1
  54. Zare I58

Source: Frontiers in Endocrinology Published:2023


Abstract

Background: Kidney dysfunction is a risk factor for cardiovascular disease and chronic kidney disease. Herein, we aimed to describe the attributable burden of kidney dysfunction at the national and sub-national levels in Iran. Methods: The Global Burden of Disease (GBD) 2019 data were extracted on the deaths, disability-adjusted life years (DALYs), years of life lost, and years lived with disability attributed to the risk factor of kidney dysfunction by age and sex at the national and provincial levels from 1990-2019. Also, risk exposure was reported by summary exposure value (SEV) with a range of 0 to 100. The estimated values were based on a comparative risk assessment framework. Results: In 2019, the age-standardized death rate and age-standardized DALYs rate attributable to kidney dysfunction were 58.2 (95% uncertainty interval of 48.8-68.1) and 1127.2 (981.1-1282.7) per 100,000 population in Iran, respectively. Also, the Sistan and Baluchistan province (1729.3 [1478.3-2006.4]) and the province of Tehran (681.9 [571.4-809.8]) had the greatest and lowest age-standardized DALYs rates, respectively. Nationally, SEVs increased from 22.8 to 26.2. The age-standardized burden attributable to kidney dysfunction had a positive association with age advancement. The attributable age-standardized deaths and DALYs rates in all socio-demographic index regions decreased from 1990-2019. Also, the highest and lowest attributable age-standardized DALYs rates of kidney dysfunction came from ischemic heart disease and peripheral artery disease in 2019, respectively. Conclusion: Although the attributed age-standardized DALYs and death rates decreased from 1990-2019, risk exposure increased and remains a crucial risk factor in Iran. Therefore, policymakers should consider preparing a preventive program that takes into account different levels of prevention of kidney dysfunction. Copyright © 2023 Nejadghaderi, Saeedi Moghaddam, Keykhaei, Shobeiri, Rezaei, Rezaei, GBD 2019 Iran Kidney Dysfunction Collaborators, Naghavi, Larijani and Farzadfar.
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