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Mortality and Disability-Adjusted Life Years in North Africa and Middle East Attributed to Kidney Dysfunction: A Systematic Analysis for the Global Burden of Disease Study 2019 Publisher

Summary: How does kidney dysfunction affect heart health in the Middle East? Research suggests it significantly raises the risk of heart disease and stroke, causing more deaths than kidney disease itself. #KidneyHealth #HeartDisease

Rashidi MM1, 2 ; Moghaddam SS1, 106 ; Azadnajafabad S1 ; Mohammadi E1, 3 ; Khalaji A1, 3 ; Malekpour MR1 ; Keykhaei M1, 4 ; Rezaei N1, 5 ; Esfahani Z1 ; Rezaei N1, 5 ; Mokdad AH104, 105 ; Murray CJL104, 105 ; Naghavi M104, 105 ; Larijani B5 Show All Authors
Authors
  1. Rashidi MM1, 2
  2. Moghaddam SS1, 106
  3. Azadnajafabad S1
  4. Mohammadi E1, 3
  5. Khalaji A1, 3
  6. Malekpour MR1
  7. Keykhaei M1, 4
  8. Rezaei N1, 5
  9. Esfahani Z1
  10. Rezaei N1, 5
  11. Mokdad AH104, 105
  12. Murray CJL104, 105
  13. Naghavi M104, 105
  14. Larijani B5
  15. Farzadfar F1, 5
  16. Abbasikangevari M1
  17. Abbasikangevari Z1, 2
  18. Elhafeez SA6
  19. Abdelsalam S7
  20. Abdoun M8
  21. Abugharbieh E9
  22. Ahmad A10
  23. Ahmed A11, 12
  24. Alazzam S13
  25. Alraddadi RM14
  26. Altammemi AB15, 16
  27. Dehkordi JA17, 18
  28. Behghadami MA19, 20
  29. Arabloo J21
  30. Athar M22, 23
  31. Athari SS24
  32. Babaei M25, 26
  33. Babamohamadi H27
  34. Baghcheghi N28
  35. Bagherieh S29
  36. Baradaran HR30, 31
  37. Bhagavathula AS32
  38. Bhojaraja VS33
  39. Hashemi MB34
  40. Campos LA35, 36
  41. Dehghan A37
  42. Elhadi M38
  43. Elhuneidi W39
  44. Fatehizadeh A40
  45. Feizkhah A41
  46. Ghadirian F42
  47. Gholami A43, 44
  48. Hamidi S45
  49. Hassankhani H46, 47
  50. Heidariforoozan M1, 48
  51. Hessami K49, 50
  52. Hezam K51, 52
  53. Hosseini MS53
  54. Hoveidamanesh S54
  55. Irilouzadian R48, 55
  56. Jahrami H56, 57
  57. Jamialahmadi T58, 59
  58. Jayapal SK60
  59. Karasneh RA61
  60. Khan MAB62, 63
  61. Khan YH64
  62. Khatatbeh MM61
  63. Kompani F65
  64. Koohestani HR66
  65. Kuddus M67
  66. Mahjoub S68, 69
  67. Mahmoodpoor A70
  68. Rad EM71
  69. Malik AA72, 73
  70. Mallhi TH64
  71. Mobayen M74
  72. Mohammadi F75
  73. Mohan S76, 77
  74. Momtazmanesh S1, 3
  75. Natto ZS78, 79
  76. Nejadghaderi SA1, 48
  77. Okatialiabad H80
  78. Rashedi S1, 81
  79. Rashidi A82
  80. Rashidi M83
  81. Mohamed Redwan EM84, 85
  82. Saad AMA86
  83. Sharifaskari FS87
  84. Sahebkar A88, 89
  85. Saki M90
  86. Samy AM91
  87. Shaker E1, 3
  88. Shetty JK92
  89. Shorofi SA93, 94
  90. Tabish M95
  91. Taherkhani A96
  92. Umair M97, 98
  93. Vahabi SM99
  94. Yazdanpanah F100, 101
  95. Yigit A102
  96. Zahir M103
  97. Zangiabadian M48

Source: Clinical Kidney Journal Published:2024


Abstract

Background. The study aimed to estimate the attributable burden to kidney dysfunction as a metabolic risk factor in the North Africa and Middle East (NAME) region and its 21 countries in 1990-2019. Methods. The data used in this study were obtained from the Global Burden of Diseases (GBD) 2019 study, which provided estimated measures of deaths, disability-adjusted life years (DALYs), and other epidemiological indicators of burden. To provide a better insight into the differences in the level of social, cultural, and economic factors, the Socio-Demographic Index (SDI) was used. Results. In the NAME region in 2019, the number of deaths attributed to kidney dysfunction was 296 632 (95% uncertainty interval: 249 965-343 962), which was about 2.5 times higher than in the year 1990. Afghanistan, Egypt, and Saudi Arabia had the highest, and Kuwait, Turkey, and Iran (Islamic Republic of) had the lowest age-standardized rate of DALYs attributed to kidney dysfunction in the region in 2019. Kidney dysfunction was accounted as a risk factor for ischemic heart disease, chronic kidney disease, stroke, and peripheral artery disease with 150 471, 111 812, 34 068, and 281 attributable deaths, respectively, in 2019 in the region. In 2019, both low-SDI and high-SDI countries in the region experienced higher burdens associated with kidney dysfunction compared to other countries. Conclusions. Kidney dysfunction increases the risk of cardiovascular diseases burden and accounted for more deaths attributable to cardiovascular diseases than chronic kidney disease in the region in 2019. Hence, policymakers in the NAME region should prioritize kidney disease prevention and control, recognizing that neglecting its impact on other diseases is a key limitation in its management. © The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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