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Green Synthesis of Biogenic Cu/Fe3o4 Nanocomposite Using the Eriobotrya Japonica Seed Extract Against Pathogenic Bacteria Publisher



Joharian M1 ; Mojarab M1 ; Darvishi E2 ; Khosravi H1 ; Nazari V1 ; Varnamkhasti BS1 ; Mirsadeghi S3
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Nanobiotechnology, Faculty of biotechnology, Amol University of Special Modern Technologies, Amol, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, P.O. BOX 1411713137, Tehran, Iran

Source: Journal of Molecular Structure Published:2022


Abstract

In this work, we designed an environmentally sound approach for green biosynthesis of the Cu/Fe3O4 with antibacterial effects using Eriobotrya japonica seed extract as reducing and stabilizing agents. The effects of synthesis factors, such as cation concentrate, the mass of plant extract, mass of Fe3O4 and extraction temperature, on the size of Cu/Fe3O4 nanocomposite were considered and optimized. Different techniques characterized the successful green synthesized Cu/Fe3O4 nanocomposite. Then, antibacterial properties of Cu/Fe3O4 nanocomposite were studied. In addition, the Fe3O4 NPs have low antibacterial activity, but when they synthesize with Cu NPs, the Cu/Fe3O4 nanocomposite displays more antimicrobial activity. The results of the antibacterial properties of biogenic nanocomposite showed that a significant effect on Gram-negative bacteria compared with gram positive. The antibacterial properties mechanism confirmed that the nanocomposites attached to the bacterial surface, disrupted the structure of the bacteria, afterwards interpenetrated cells and inhibited protein activity, finally led to bacteria apoptosis. As a result, Cu/Fe3O4 nanocomposite can be an excellent option in the green nanotechnology for the development of antibacterial agent based on nanomaterials. © 2022 Elsevier B.V.