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Effects of Mechanical Properties of Carbon-Based Nanocomposites on Scaffolds for Tissue Engineering Applications: A Comprehensive Review Publisher



Eivazzadehkeihan R1 ; Sadat Z1 ; Lalebeigi F1 ; Naderi N1 ; Panahi L1 ; Ganjali F1 ; Mahdian S1 ; Saadatidizaji Z1 ; Mahdavi M2 ; Chidar E1 ; Soleimani E1 ; Ghaee A3 ; Maleki A1 ; Zare I4
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Catalysts and Organic Synthesis Research Laboratory, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, P.O. Box 14395-1561, Tehran, Iran
  4. 4. Research and Development Department, Sina Medical Biochemistry Technologies Co. Ltd, Shiraz, 7178795844, Iran

Source: Nanoscale Advances Published:2023


Abstract

Mechanical properties, such as elasticity modulus, tensile strength, elongation, hardness, density, creep, toughness, brittleness, durability, stiffness, creep rupture, corrosion and wear, a low coefficient of thermal expansion, and fatigue limit, are some of the most important features of a biomaterial in tissue engineering applications. Furthermore, the scaffolds used in tissue engineering must exhibit mechanical and biological behaviour close to the target tissue. Thus, a variety of materials has been studied for enhancing the mechanical performance of composites. Carbon-based nanostructures, such as graphene oxide (GO), reduced graphene oxide (rGO), carbon nanotubes (CNTs), fibrous carbon nanostructures, and nanodiamonds (NDs), have shown great potential for this purpose. This is owing to their biocompatibility, high chemical and physical stability, ease of functionalization, and numerous surface functional groups with the capability to form covalent bonds and electrostatic interactions with other components in the composite, thus significantly enhancing their mechanical properties. Considering the outstanding capabilities of carbon nanostructures in enhancing the mechanical properties of biocomposites and increasing their applicability in tissue engineering and the lack of comprehensive studies on their biosafety and role in increasing the mechanical behaviour of scaffolds, a comprehensive review on carbon nanostructures is provided in this study. © 2024 RSC.