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Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate)/Chitosan/Carbon Nanotubes Electrospun Scaffold: Structure and Mechanical Properties Publisher



Nikbakht M1 ; Karbasi S2 ; Rezayat SM1, 3 ; Tavakol S4 ; Sharifi E5, 6
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technology in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Biomaterials and Tissue Engineering, School of Advanced Technology in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Polymer-Plastics Technology and Materials Published:2019


Abstract

In this study, a combination of poly (3-hydroxybutyrate) (PHB), chitosan (Cs), multiwall carbon nanotubes (MWNTs), and different concentrations of Hyaluronic Acid (HA) were electrospun. The results showed that the produced nanofibers are uniform. Incorporation of HA, Cs and MWNTs reduced the water contact angle and made the scaffolds more hydrophilic. The porosity of the scaffolds was in the range of 80–88%. The presence of MWNTs increased the tensile strength of scaffolds and different concentrations of HA had no much diverse effects. In conclusion, the PHB-Cs-MWNTs-HA 10% electrospun scaffold could be a good candidate for cartilage tissue engineering applications. © 2019, © 2019 Taylor & Francis.
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