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The Role of Long Non-Coding Rnas and Circular Rnas in Cervical Cancer: Modulating Mirna Function Publisher



Heidariezzati S1 ; Moeinian P2 ; Ahmadiannejad B3 ; Maghbbouli F4 ; Abbasi S5 ; Zahedi M6 ; Afkhami H7, 8 ; Shadab A9, 10 ; Sajedi N11
Authors
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Authors Affiliations
  1. 1. School of Nursing and Midwifery, Bonab University of Medical Sciences, Bonab, Iran
  2. 2. Department of Medical Genetics and Molecular Biology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. School of Nursing and Midwifery, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
  4. 4. Tabriz Islamic Azad University of Medical Sciences, Tabriz, Iran
  5. 5. Department of obstetrics and gynecology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  7. 7. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
  8. 8. Department of Medical Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
  9. 9. Department of Immunology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  10. 10. Iran University of Medical Sciences, Deputy of Health, Tehran, Iran
  11. 11. Department of Anatomy, Faculty of Medicine, Qom Medical Sciences, Islamic Azad University, Qom, Iran

Source: Frontiers in Cell and Developmental Biology Published:2024


Abstract

Cervical cancer (CC) is a primary global health concern, ranking as the fourth leading cause of cancer-related death in women. Despite advancements in prognosis, long-term outcomes remained poor. Beyond HPV, cofactors like dietary deficiencies, immunosuppression, hormonal contraceptives, co-infections, and genetic variations are involved in CC progression. The pathogenesis of various diseases, including cancer, has brought to light the critical regulatory roles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). The aberrant expression of these miRNAs, lncRNAs, and circRNAs plays a pivotal role in the initiation and progression of CC. This review provides a comprehensive summary of the recent literature regarding the involvement of lncRNAs and circRNAs in modulating miRNA functions in cervical neoplasia and metastasis. Studies have shown that lncRNAs and circRNAs hold great potential as therapeutic agents and innovative biomarkers in CC. However, more clinical research is needed to advance our understanding of the therapeutic benefits of circRNAs and lncRNAs in CC. Copyright © 2024 Heidari-Ezzati, Moeinian, Ahmadian-Nejad, Maghbbouli, Abbasi, Zahedi, Afkhami, Shadab and Sajedi.
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