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Hyperthermia and Biological Investigation of a Novel Magnetic Nanobiocomposite Based on Acacia Gum-Silk Fibroin Hydrogel Embedded With Poly Vinyl Alcohol Publisher



Pajoum Z1 ; Aliabadi HAM2 ; Mohammadi A3 ; Sadat Z3 ; Kashtiaray A3 ; Bani MS4 ; Shahiri M5 ; Mahdavi M6 ; Eivazzadehkeihan R3 ; Maleki A3 ; Heravi MM1
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, School of Physics and Chemistry, Alzahra University, PO Box 1993891176, Vanak, Tehran, Iran
  2. 2. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  3. 3. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  4. 4. Department of Optics and Photonics, Wroclaw University of Science and Technology, Wroclaw, Poland
  5. 5. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  6. 6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Heliyon Published:2024


Abstract

The design and synthesis of biocompatible nanostructures for biomedical applications are considered vital challenges. Herein, a nanobiocomposite based on acacia hydrogel, natural silk fibroin protein, and synthetic protein fibers of polyvinyl alcohol was fabricated and magnetized with iron oxide nanoparticles (Fe3O4 MNPs). The structural properties of the hybrid nanobiocomposite were investigated by essential analyses such as Fourier Transform Infrared Spectrometer (FTIR), Field emission scanning electron microscopy (FE-SEM), and X-ray powder diffraction)XRD(analyses, Thermogravimetric and Differential thermogravimetric analysis (TGA-DTG), Vibrating-sample magnetometry (VSM), and Energy Dispersive X-Ray Analysis (EDX). The biological activities and functional properties of the prepared magnetic nanobiocomposite were studied. Results proved that this nanobiocomposite is non-toxic to the healthy HEK293T cell line. In addition, the synthesized nanobiocomposite showed an approximately 22 % reduction in cell viability of BT549 cells after 72 h. All results confirmed the anti-cancer properties of nanobiocomposite against breast cancer cell lines. Therefore, the prepared nanobiocomposite is an excellent material that can use for in-vivo application. Finally, the hyperthermia application was evaluated for this nanobiocomposite. The SAR was measured 93.08 (W/g) at 100 kHz. © 2024 The Authors
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